Introduction Ultraviolet radiation (UVR) in sunlight is the most important cause of skin damage and aging.'"' This form of radiation causes skin aging by several mechanisms, including free-radical generation, DNA damage, collagen breakdown, the induction of immune defects, and cell death.'-5 In addition, repeated damage to the skin by sunburn is a primarily risk factor for the development of cu...

Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is maintained by mesenchymal stem cells in inner layer dermis and epidermal stem...

DNA damage induced by UV radiation is a critical event in skin photocarcinogenesis. However, the role of racial/ethnic origin in determining individual UV sensitivity remains unclear. In this study, we examined the relationships between melanin content and DNA damage induced by UV exposure in situ in normal human skin of different racial/ethnic groups, phototypes, and UV sensitivities. The mini...

Introduction: Skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using VARSKIN2. Materials and Methods: In this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90Sr/90Y, 147Pm, 32P beta emitter radioisotopes by using input parameters: activity of source, ...

Normal skin is composed of epidermis and dermis. Skin is susceptible to radiation damage because it is a continuously renewing organ containing rapidly proliferating mature cells. Radiation burn is a damage to the skin or other biological tissues caused by exposure to radiofrequency energy or ionizing radiation. Acute skin reaction is the most frequently occurring side effect of radiation thera...