toll like receptors (tlrs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens. in their bridging role, tlr downstream signals link innate and adaptive immunity, particularly by mediating dc maturation and activation of pathogen specific t lymphocytes. these pathways lead to the act...

despite the fact that higher bmi is a risk factor for, wheeze ever, wheeze and dyspnea in the last 12 months, and diagnosed asthma, higher bmi is not a risk factor for obstructive pattern in pulmonary function test. chronic mucocutaneous candidiasis (cmcc) refers to a group of immunodeficiencies, characterized by persistent or recurrent infections of the skin, nails, and mucus membranes caused ...

objective: the use of bacterial plasmids carrying specific genes of pathogens as genetic vaccines is a relatively new technique for induction of cellular immune responses against microbial pathogens. mechanisms of production of specific immune responses against these vaccines are not still completely understood. therefore, it is necessary to examine various routes of inoculation to find the bes...

Mycobacterium avium spp. paratuberculosis (MAP) causes a persistent infection and chronic inflammation of the gut in ruminants leading to bacterial shedding in feces in many infected animals. Although there are often strong MAP-specific immune responses in infected animals, immunological correlates of protection against progression to disease remain poorly defined. Analysis of cross-sectional d...

exposure to high dosages of sulfur mustard (sm) can cause bone marrow depression, immune system suppression, impairment of the immune functions, and eventually results in diseases due to secondary immune disorders. in this article, we have studied the effects of this poison on iranian veterans by analysis of related published studies. in a systematic search, the effects of sm gas on iranian vic...

this study was conducted to compare the effects of different illumination programs on the cellular and humoral immune system using 320 one day–old male broilers (arian 386) in a completely randomized design of 8 replications (10 birds each). the four assayed lighting schedules were comprised of: 1- continuous lighting (control), 2- decrease then sudden increase of lighting, 3- decreasing-gradua...