Background: Aphasia is a common outcome of Cerebrovascular Accident (CVA) in which clinical interventions have limited effectiveness. Some evidence suggests that noninvasive stimulation of the brain can have beneficial effects in the treatment of CVA induced aphasia. In patients with motor aphasia, repetitive Transcranial Magnetic Stimulation (rTMS) is used to facilitate long-term improvement i...

High- (?5Hz), but not low-frequency (?1Hz) rTMS (repetitive Transcranial Magnetic Stimulation) of the contralateral primary motor cortex (M1) can induce transient analgesic effects [5]. However, impact TMS frequency and pulse number remains poorly understood may present an opportunity to optimise efficacy promote long-term effects. Prior work indicated that a single session consisting 2,000, 50...

Introduction: Electrical low-frequency stimulation (LFS) has antiepileptic effect, but the role of different stimulation parameters on this effect has not been determined. In this study the effect of different LFS parameters (intensity, pulse duration and train duration) on piriform-cortex kindled seizures was investigated. Methods: Seizure was produced in animals using kindling model of ep...

Invasive deep brain stimulation has proven to be clinically therapeutic for patients with drug-refractory epilepsy. The aim of this study was develop a novel transcranial electrical device as noninvasive modality seizure treatment. We fabricated and tested it in four swine brains depth electrodes surgically implanted under neuro-navigation. Stimulation two high-frequency alternating currents us...

The effects of chronic morphine administration on the development of long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices using primed-bursts tetanic stimulation. Significant enhancement of orthodromic population spike (OPS) was found for all stimulus intensities after tetanic stimulation. OPS enhancement was greates...