BACKGROUND Abnormal patterns of metabolite levels have been detected by magnetic resonance spectroscopy in frontostriatal regions of individuals meeting DSM-IV criteria for methamphetamine dependence, but less is known about the effects of drug abstinence on metabolite levels. OBJECTIVE To assess the effects of long-term methamphetamine use and drug abstinence on brain metabolite levels. DE...

background & aim: understanding the relative effectiveness of different kinds of therapeutic methods on abstinence is very important, considering the fact that important variables such as self-efficacy beliefs in addicted adolescents, predicts the variance of marijuana and alcohol use up to 69 and 50 percent respectively. this study was aimed to compare the effectiveness of two different therap...

AIMS More than half of infants exposed to opioids in utero develop neonatal abstinence syndrome (NAS) of severity to require pharmacological therapy. Current treatments are associated with prolonged hospitalization. We sought to optimize the dose of sublingual buprenorphine in the treatment of NAS. DESIGN Randomized, Phase 1, open-label, active-control clinical trial comparing sublingual bupr...

Prenatal opioid agonist therapy with methadone or buprenorphine prevents maternal illicit opioid use and withdrawal and improves pregnancy outcomes compared to heroin use alone. Historically, methadone has been the first-line opioid agonist therapy for pregnant opioid dependent women; in recent years buprenorphine has become first-line treatment for some opioid dependent pregnant women. While t...

Background: Among different factors, self-efficacy is one of the most suitable components for predicting smoking behavior among adolescents. Therefore, it is essential to design a native tool to measure this high-risk behavior in adolescents and implement prevention programs in this age group. Aim: This study aimed to design and validate a smoking abstine...

This paper describes an epidemiologic-based sample of individuals who remitted from alcohol abuse or alcohol dependence, both with and without treatment, to abstinence or moderate drinking. Inspection of the severity, onset, and duration of alcohol problems experienced by these individuals suggests that there may be two primary categories of drinkers with distinct pathways to remission. The fir...

J t oduction T?I!amine, vitamin Bl, is essential for aerobic glucose metabolism. Thiamine deficiency (TD), a frequent complication of alcoholism caused by decreased thiamine absorption, may result in brain damage known as Wernicke’s encephalopathy. In chronic alcoholics, neurobehavioral deficits related to TD and brain glucose metabolism have been shown to recover during abstinence. However, th...