The Wnt-Wingless (Wg) pathway regulates development through precisely controlled signaling. In this study, we show that intracellular trafficking regulates Wg signaling levels. In Drosophila melanogaster cells stimulated with Wg media, dynamin or Rab5 knockdown causes reduced Super8XTOPflash activity, suggesting that internalization and endosomal transport facilitate Wg signaling. In the wing, ...

Insect wing is a key evolutionary innovation for insect radiation, but its origins and intermediate forms are absent from the fossil record. To understand the ancestral state of the wing, expression of three key regulatory genes in insect wing development, wingless (wg), vestigial (vg), and apterous (ap) was studied in two basal insects, mayfly and bristletail. These basal insects develop dorsa...

The Drosophila signaling molecule Wingless (Wg) plays crucial roles in cell-cell communications during development. In the developing nervous system, a previous study has shown that Wg acts non-autonomously to specify the fate of a specific neuronal precursor, NB4-2 (Q. Chu-LaGraff and C. Q. Doe (1993) Science 261, 1594-1597). The lack of autocrine specification of NB4-2 in Wg-expressing cells ...

In this paper we discuss the possibility to represent synthetically semistructured information via a loose notion of schema: we say that data are semistructured when, although some structure is present, it is not as strict, regular, or complete as the one required by the traditional database management systems. Our proposal is based on WG-Log, a graph based language for the representation of WW...

Nature is a home handywoman. Constrained by evolution, she does the job with the tools at hand, using a screwdriver for a hammer if necessary. This is well illustrated by the way particular cell signaling systems, such as that mediated by Wingless (Wg) in Drosophila and its Wnt homologs in vertebrates, direct diverse developmental decisions. The Wg/Wnt signaling system has been the subject of i...

The WG stream ciphers are based on the WG (Welch-Gong) transformation and possess proved randomness properties. In this paper we propose nine new hardware designs for the two classes of WG(29, 11) and WG-16. For each class, we design and implement three versions of standard, pipelined and serial. For the first time, we use the polynomial basis (PB) representation to design and implement the WG(...

Climate is a complex system which is changing mainly due to the increase of greenhouse gases. Because of the importance of climate change and the effects it can have on water resources, in recent years, this topic has been taken into consideration for different basins on Earth. The objective of this study is to investigate the effects of climate change and forecasting meteorological variables o...

The eyegone (eyg) gene encodes Eyg, a transcription factor of the Pax family with multiple roles during Drosophila development. Although Eyg has been shown to act as a repressor, nothing is known about the mechanism by which it represses its target genes. Here, we show that Eyg forms a protein complex with heterochromatin protein 1a (HP1a). Both proteins bind to the same chromatin regions on po...

This study aims to evaluate effects of two downscaling methods; change-factor and statistical downscaling on therunoff of the Azam-Harat River located at Yazd province (with an arid climate) of Iran, under the A2 emission scenariofor the period of 2010-2039. For this purpose, CGCM3-AR4 model; a rainfall-runoff conceptual model, IHACRES; twodownscaling models, Change Factor and LARS-WG were appl...

Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is ...