We study four kinds of 1/4 BPS solutions in massive IIA supergravity corresponding to D8-D0-F1, D8-D2, D8-D4 and D8-D6-NS5 systems. We show that these solutions are reproduced without making nontrivial assumptions by using supersymmetry conditions. D8D2 and D8-D4 solutions are represented by harmonic functions, as usual, while the other two are represented by solutions of non-linear differentia...

INTRODUCTION We assessed the relationship between the plasma concentration of gefitinib and its efficacy in Japanese patients with advanced non-small cell lung cancer (NSCLC). METHODS Plasma trough levels of gefitinib were measured on days 3 (D3) and 8 (D8) by high-performance liquid chromatography in 44 patients with advanced NSCLC treated with 250 mg gefitinib daily. Eligibility criteria in...

The IMV envelope protein D8 is an adhesion molecule and a major immunodominant antigen of vaccinia virus (VACV). Here we identified the optimal D8 ligand to be chondroitin sulfate E (CS-E). CS-E is characterized by a disaccharide moiety with two sulfated hydroxyl groups at positions 4' and 6' of GalNAc. To study the role of antibodies in preventing D8 adhesion to CS-E, we have used a panel of m...

The German infectious disease surveillance system revealed an increase of epidemic keratoconjunctivitis (EKC) from an average of 320 cases/year (2001 to 2010) up to 2146 and 1986 cases in 2012 and 2013, respectively. From November 2011 until December 2013 (epidemic period) 85% of typed isolates were human adenovirus type 8 (HAdV-D8), whereas only low level circulation (19%) of HAdV-D8 was obser...

Up to now chiral type IIA vacua have been mostly based on intersecting D6-branes wrapping special Lagrangian 3-cycles on a CY3 manifold. We argue that there are additional BPS Dbranes which have so far been neglected, and which seem to have interesting model-building features. They are coisotropic D8-branes, in the sense of Kapustin and Orlov. The D8-branes wrap 5-dimensional submanifolds of th...