Compared with the other class B multimodular penicillin- binding proteins (PBPs), the low-affinity PBP5 responsible for penicillin resistance in Enterococcus hirae R40, has an extended non-penicillin-binding module because of the presence of an approximately 110-amino-acid E-46(-)D-160 insert downstream from the membrane anchor. Expression of pbp5 genes lacking various parts of the insert-encod...

BACKGROUND Adhesion of leukocytes to the extracellular matrix and to other cells is mediated by members of the integrin family of adhesion molecules. Src family kinases are activated upon integrin-mediated adhesion. In lymphocytes, CD45 is a leukocyte-specific transmembrane protein tyrosine phosphatase that activates Src family kinases associated with B-cell and T-cell antigen receptor signalin...

Zheng Xu1∗, Mário A. T. Figueiredo2, Xiaoming Yuan3, Christoph Studer 4, Tom Goldstein1 1Department of Computer Science, University of Maryland, College Park, MD 2Instituto de Telecomunicações, Instituto Superior Técnico, Universidade de Lisboa, Portugal 3Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong 4Department of Electrical and Computer Engineering, Cornell ...

The paper presents experimental research findings for the regimes (puffing and micro-explosion) integral characteristics of fragmentation two- three-component droplets on a heated substrate, as illustrated by emulsions slurries. main droplet components were water with fluorophore Rhodamine B (9 vol%), tetradecane (91 vol%) bituminous coal particles measuring 5–110 µm (0.05–0.27 wt%). conditions...

Baloxavir marboxil has been used for influenza treatment since March 2018 in Japan. After baloxavir treatment, the most frequently detected substitution is Ile38Thr polymerase acidic protein (PA/I38T), and this reduces susceptibility A viruses. To rapidly investigate frequency of PA/I38T (H1N1)pdm09 (H3N2) viruses clinical samples, we established a rapid real-time system to detect single nucleo...

Isolation, purification and physicochemical properties of the antibiotic complex YA-56, a family of phleomycin-bleomycin group, are described. The antibiotic YA-56 complex was found to be composed mainly of two active components named YA-56X and Y. These components were clearly differentiated from the reported phleomycins and bleomycins by their physicochemical properties. However, by direct co...