background : to identify correlates related to retention time of a cohort study of the opioid-dependent patients participating in the methadone maintenance treatment (mmt) program offered by a major addiction treatment clinic in tehran, iran between april 2007 and march 2011. methods : several parametric survival models assuming weibull, log-normal and log-logistic distributions were compared t...

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug-seeking and drug-taking behaviours. Given the significant detrimental effects of this disease both socially and economically, a considerable amount of research has been dedicated to understanding a number of issues in addiction, including behavioural and neuropharmacological factors that contribute to the d...

Symptoms of addictive disorders often manifest as periodic episodes of sudden relapse followed by relatively long periods of recovery. For certain types of addiction, a relapse is precipitated by a state of elevated well-being (hyperthymia) wherein cravings supersede cessation efforts. A relapse satiates cravings temporarily, but is usually followed by a state of depression, which slowly improv...

Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction. Here we show that blockade of drug memory reconsolidation, through infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impair...

Health Programs paints a different picture. In a retrospective case control study, Paris and Canavan compared 32 anesthesiologists with 36 physician controls, and after an average follow-up of 7.5 yr, there was no difference in the relapse rates between these 2 groups. Likewise, the outcomes of residents did not differ from attending physicians. A similar report from Pelton involving 255 physic...

The need for effective treatments for addiction and dependence to the illicit stimulant methamphetamine in primary care settings is increasing, yet no effective medications have been FDA approved to reduce dependence [1]. This is partially attributed to the complex and dynamic neurobiology underlying the various stages of addiction [2]. Therapeutic strategies to treat methamphetamine addiction,...