Endometrial carcinoma (EC) is an epithelial malignant tumor that occurs in the endometrium. It of great significance to explore new targets for improving prognosis endometrial cancer. Chikusetsusaponin Iva (CHI) a plant compound extracted from Panacis japonica which has multiple biological activities, including anti-inflammation and anti-tumor effects. However, its possible effects on EC are un...

Background: Molecular targeted therapy by different cell death inducers are recently considered in cancer therapy. The aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (MCF-7). The pattern of cell death in MCF-7 cells following the exposure to cisplatin and caffeine in individual and combination form...

Although adult murine B cells can be stimulated to proliferate by Igm receptor cross-linking, we and others have shown that these cells will undergo apoptosis in vitro in a dose-, time- and temperature-dependent manner with polyclonal but not monoclonal anti-IgM, To test the role of c-myc and cell cycle progression in B cell apoptosis, we examined normal, Sp6 anti-TNP lg and E micro-myc transge...

Background: Colorectal cancer (CRC) is attributed as one of the most common malignancies worldwide. CD133 molecule, as a pentaspan transmembrane glycoprotein, confers stem cell-related characteristics, including self-renewal and multi-directional differentiation capability. CD133 plays important roles in the progression of CRC by conferring apoptotic resistance and migration ab...

Background: Noscapine is a water soluble alkaloid with antitussive property and very less toxicity. It is obtained from the Papaveraceae family. Recently, new pharmacological properties such as anticancer, anti stroke and anti-angiogenic effects are introduced. There is no scientific report on noscapine effect on reproductive system. The aim of present study was to determine in vitro effect of ...

MicroRNAs (miRNAs) involved in regulation of the genes. The CCAAT/enhancer-binding protein-α (CEBPα) is a crucial transcription factor for normal hematopoiesis and cell cycle that frequently disrupted in human acute myeloid leukemia (AML). The miR-182 up-regulation in several malignant diseases such as AML was reported, in the other hand bioinformatics analysis revealed CEBPα targeted by miR-18...

Abstract: Medicinal plants and herbs are commonly used in the world to treat various human disorders. Artemisia judaica is one of these herbal species that medicine due its contents many bioactive compounds such as; flavonoids, lactones, essential oil sesqui-terpenoids. It was traditional medicines as an anthelmintic, antispasmodic, anti-rheumatic, antibacterial agent. In recent years, anti-bac...

Purpose: To determine the effect of sevoflurane (SE) on neuronal apoptosis, and mechanism involved.Methods: Sixty healthy male Sprague-Dawley rats were assigned to control, model SE groups. Sham surgery was performed in control group, while middle cerebral artery infarction (MCAO) established group. The expression HO-1 mRNA determined by quantitative real-time polymerase chain reaction (qRT-PCR...