OBJECTIVE(S) Trichophyton rubrum (T. rubrum) is one of the most common dermatophytes worldwide. This fungus invaded skin appendages of humans and animals. Recently, resistance to antifungal drugs as well as appearance of side effects due to indication of these kinds of antibiotics has been reported. Besides, using some plant extracts have been indicated in herbal medicine as an alternative trea...

Aim: This study was conducted to investigate the in vitro antifungal activity of garlic (Allium sativum) on some pathogenic fungi. Study Design: This is a comparative evaluation report on garlic as an antifungal agent. Place and Duration: Department of mycology, Veterinary Research institute, between June-October 2013. Methodology: Samples of garlic were obtained from a local market. It was tho...

We evaluated the preventive and therapeutic effects of aqueous suspensions of garlic, tomato, and garlic + tomato in the development of experimental Ehrlich tumors in mice. The aqueous suspensions (2%) were administered over a short term for 30 days before tumor inoculation and 12 days afterward, and suspensions at 6% were administered for 180 days before inoculation and for 12 days afterward. ...

This study evaluated the influence of dietary garlic (Allium sativum) extract on survival rate and changes in blood and immune parameters of Common carp (Cyprinus carpio), fed with two different concentrations of aqueous garlic extract after exposure to spring viremia of carp virus (SVCV). The experiments have executed in two steps: Firstly, 270 fingerlings of Common carp with an average weight...

the objective of present study was to investigate the effects of aqueous garlic extracts, vitamin e and n-acetylcysteine on lead-induced lipid peroxidation, changes in antioxidant defense system and semen quality in the rat testes. twenty-five male rats were divided into five groups. animals within different treatment groups were maintained on their respective diets for 35 days as follows: grou...

Several reports suggest garlic supplements may inhibit the metabolism of cytochrome P450 (CYP) 2C9 and CYP3A4 substrates, such as warfarin and saquinavir. To characterize the effects of garlic extract on CYP2C9 and CYP3A4 enzyme activity immortalized human hepatocytes (Fa2N-4 cells) were exposed to garlic extract (0-200 μg/mL). CYP2C9 and CYP3A4 enzyme activities were evaluated in parallel with...

The opportunistic human pathogen Pseudomonas aeruginosa is the predominant micro-organism of chronic lung infections in cystic fibrosis patients. P. aeruginosa colonizes the lungs by forming biofilm microcolonies throughout the lung. Quorum sensing (QS) renders the biofilm bacteria highly tolerant to otherwise lethal doses of antibiotics, and protects against the bactericidal activity of polymo...