background: bax and bcl-2 are the major members of bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. methods: in this study, the relative level of mrna expression of bax and bcl-2 genes was deter...

objective: recent evidences suggest that tumors arise from a small subpopulation of cells, the cancer stem cells (cscs) or tumor initiating cells. cscs are able to resist the conventional methods of cancer therapy due to existence of abc transporters on their surface. this leads to csc resistance and maintenance resulting in post-treatment relapse and metastasis. therefore, precise identificati...

results: the only significant difference was the older age of the malignant group vs. benign group (p = 0.001) regarding demographic findings. as concerns the clinical symptoms, presence of abdominal discomfort in pre-diagnosis period was the only significant parameter in malignant group (p = 0.001). additionally, data analysis of patients as a total group showed that specificity (96.4%), posit...

a large number of people are affected by cancer and the primeval history of this malady has attracted attention toward complementary and alternative therapies to manage this disease. the present study has performed a survey on cancer in the iranian traditional medicine during the islamic era (itm) by focusing on cancer terminologies and related diseases over a millennium, from medieval to the e...

breast cancer  patients  are  susceptible to  infections such  as  candidiasis. due  to  the importance and the role of matrix metalloproteinases (mmp) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of mmps -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in breast cancer bearing mice in the presence of systemic candida ...

breast cancer is a malignant tumor and the most common cancer among american women that starts from cells of the breast. the growth of the size of data exceeds the ability of humans to analyze the data. so we need some intelligent machines that can analyze datasets intelligently for us. we propose a multi nominal logit model to evaluate correlation between risk factors of breast tumor. our mode...

Cancer immunotherapy refers to any intervention that leverages the immune system to eliminate a malignancy. Successful cancer immunotherapies generate an anti-cancer response that is systemic, specific, and durable and overcome to the primary limitations of traditional cancer treatment modalities. In this review paper, the effective methods in immune system to treat cancer, such as immunosuppre...