نتایج جستجو برای: cellular and molecular modification
تعداد نتایج: 16963742 فیلتر نتایج به سال:
background: zinc (zn) as an important trace element is essential for testicular development and spermatogenesis. molecular mechanism of zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (mt). our objective was to determine the effect of zn on two important isoforms of mt, mt1m and mt1g genes expression on testicular sertoli cell...
in this project, 4,4?-methylenebis(3-chloro-2,6-diethyl trimellitimidobenzene) as a diacid, was prepared by the reaction of trimellitic anhydride (tma) with 4,4?-methylenebis(3-chloro-2,6-diethylaniline) (mcdea). the novel poly(amide-imide) (pai) was synthesized from the reaction of 4,4?-methylenebis(3-chloro-2,6-diethyl trimellitimidobenzene) as a diacid with mcdea under green condition using ...
N6-methyladenosine (m6A) modification is the most widespread and conserved internal mRNA in mammalian cells. It greatly affects genetic regulation by enhancing involvement of diverse cellular enzymes thus, plays a significant role basic life processes. Numerous studies on m6A identified FTO as crucial demethylase that participates various biological Not only does play pivotal obesity-related co...
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
Abstract During normal cellular activities Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) are produced. In addition to beneficial functions they play a critical role in cell death and prevent apoptosis. Every cell is equipped with an extensive antioxidant defense system to combat the excessive production of active radicals. Oxidative stress occurs with destruction of cellu...
Mammalian mechanistic target of rapamycine (mTOR) is a conserved serine/threonine kinase in the cellular PI3K/Akt/mTOR signaling pathway. This pathway is modified by cellular alterations such as level of energy, growth factors, stresses, as well as the increased environmental level of cancerous cytokines. In general, increase of this kinase protein function is seen in various types of cancers, ...
Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment...
Several factors have incentive role for study of aging which includes increasing of the average and maximum of human life span, the increase in percentage of elderly in the societies and proportion of the national expenditure utilized by them. The Recent views of aging indicating that aging is extremely a complex multifactorial process despite of earlier views about definite cause aging like ge...
Cardiovascular diseases are still the main cause of mortality around the world. Therefore, it is essential to develop practical means to reduce their burden. A wealth of evidence supports the role of physical exercise in attenuating many of the risk factors of cardiovascular diseases. Moreover, endurance training warrants protection against myocardial infarction. Exercise, even if performed ...
Abstract Chitosan is a versatile natural biomaterial that has been researched for range of bio-dental applications. It possesses various desirable qualities such as biocompatibility, hydrophilicity, biodegradability, and broad antibacterial (covering Gram-negative Gram-positive bacteria well fungi). Moreover, the molecular structure contains reactive functional groups, which provide numerous re...
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