The use of dense gases (DGs), particularly CO2, as solvents for pharmaceutical reformulation has attracted great attention due to the excellent tunability of their solvating power. Other attractive advantages for processing of active pharmaceutical ingredients include mild processing temperatures and limited usage of organic solvents. In this work, we applied a novel process based on the DG tec...

Nanoparticles of approximately 10nm in diameter made with chitosan or lactic acid-grafted chitosan were developed for high drug loading and prolonged drug release. A drug encapsulation efficiency of 92% and a release rate of 28% from chitosan nanoparticles over a 4-week period were demonstrated with bovine serum protein. To further increase drug encapsulation, prolong drug release, and increase...

Payloads transported over a Softwire mesh service (as defined by BGP Encapsulation Subsequent Address Family Identifier (SAFI) information exchange) often carry a number of identifiable, distinct flows. It can, in some circumstances, be desirable to distribute these flows over the equal cost multiple paths (ECMPs) that exist in the packet switched network. Currently, the payload of a packet ent...

The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...

Nanoformulation consisting of Streptomycin loaded chitosan-alginate nanoparticles were prepared using ionotropic-pregelation method and optimization was done in terms of polymer concentration, crosslinker concentration and stirring time. The optimal parameters were found to be Chitosan 0.75mg/ml, calcium chloride 1% (w/v) and stirring time 90 min. Polymer (chitosan and sodium-alginate) and cros...

This paper describes the conditions of preparation of poly(epsilon-caprolactone) (PCL) microparticles with a mean size between 5 and 10 microm, obtained by a double emulsion-solvent evaporation technique, suitable for oral vaccine delivery. Bovine serum albumin (BSA) was used as water-soluble model antigen for encapsulation. Different parameters influencing the microparticle size, the BSA loadi...

Microencapsulated dosage forms represent effective new therapeutic platforms. This special issue will cover the different interests of microencapsulation as a means to control or modify the release of drug substances from drug delivery systems. To overcome the drug stability problem, since clinical efficacies have been reported to be improved by the encapsulation of pharmaceuticals, the bioavai...

Electrostatic interaction is the driving force for the encapsulation by virus coat proteins of nanoparticles such as quantum dots, gold particles and magnetic beads for, e.g., imaging and therapeutic purposes. In recent experimental work, Daniel et al (2010 ACS Nano 4 3853-60) found the encapsulation efficiency to sensitively depend on the interplay between the surface charge density of negativ...

Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a unique soft lithography particle moldin...