Tumor-tropic properties of neural stem cells (NSCs) provide a novel approach with which to deliver targeting therapeutic genes to brain tumors. Previously, we developed a therapeutic strategy against metastatic brain tumors using a human NSC line (F3) expressing cytosine deaminase (F3.CD). F3.CD converts systemically administered 5-fluorocytosine (5-FC), a blood-brain barrier permeable nontoxic...

Paranodin/contactin-associated protein (caspr) is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in the paranodal regions of myelinated axons. We have investigated the role of its association with F3/contactin, a glycosylphosphatidyl inositol (GPI)-anchored neuronal adhesion molecule of the Ig superfamily. Paranodin was not expressed at the cell surface when tr...

BACKGROUND Alpha-particle emitting isotopes are effective novel tools in cancer therapy, but targeted delivery into tumors is a prerequisite of their application to avoid toxic side effects. Peritoneal carcinomatosis is a widespread dissemination of tumors throughout the peritoneal cavity. As peritoneal carcinomatosis is fatal in most cases, novel therapies are needed. F3 is a tumor homing pept...

The arginine-rich histone F3 has been purified by covalent affinity chromatography. By the use of activated Thiol-Sepharose 4B for the purification of cysteine containing histone F3 a highly purified protein was obtained. The simple purification procedure offers the opportunity to get larger amounts of pure histone F3 within short time.

The 3-compact group DI(2) is characterized by cohomology algebra with coefficients in the finite field F3, H∗(BDI(2); F3) = F3[x12, x16], being the rank 2 Dickson algebra. We show that DI(2) is a totally N-determined 3-compact group, compute the endomorphism monoid of DI(2), and investigate subgroups of DI(2).

PURPOSE Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells (HB1.F3) expressing Escherichia coli cytosine deaminase (CD) (HB1.F3.CD) and human interferon-β (IFN-β) (HB1.F3.CD.IFN-β) were employed against lymph node-derived metastatic color...

Let F be an n-uniform hypergraph on 2n vertices. Suppose that |F1∩F2∩F3∩F4| ≥ 2 and |F1∪F2∪F3∪ F4| ≤ n−2 holds for all F1,F2,F3,F4 ∈F . We prove that the size of F is at most (2n−4 n−2 ) for n sufficiently large.

Let F be an n-uniform hypergraph on 2n vertices. Suppose that |F1 ∩ F2 ∩ F3| ≥ 1 and |F1 ∪ F2 ∪ F3| ≤ 2n− 1 holds for all F1, F2, F3 ∈ F . We prove that the size of F is at most ( 2n−2 n−1 ) .

Let T be a 3-partite tournament. We say that a vertex v is −→ C3-free if v does not lie on any directed triangle of T . Let F3(T ) be the set of the −→ C3-free vertices in a 3-partite tournament and f3(T ) its cardinality. In a recent paper, it was proved that if T is a regular 3-partite tournament, then f3(T ) < n 9 , where n is the order of T . In this paper, we prove that f3(T ) ≤ n 12 . We ...