BACKGROUND Cisplatin (CP) as a potential drug for solid tumors produces nephrotoxicity and disturbs endothelial function. CP induced nephrotoxicity may be gender related. Nitric oxide plays a pivotal role in endothelial function and L-arginine as endogenous NO donor promotes endothelial function. The role of L-arginine in CP induced nephrotoxicity model and its gender related was investigated i...

Histological samples of organs obtained from 72 (35 male and 37 female) cynomolgus monkeys (M. fascicularis) negative control groups in 12 toxicological studies were analyzed retrospectively. The most common processes where focal accumulations exogenous pigment found 76.4% animals the lungs, non-atrophic chronic gastritis, which was observed 37.4% animals, quiescent colitis noted 36.1% cases, i...

Sex differences in human immunodeficiency virus type-1 (HIV-1) have been repeatedly suggested. Females, who account for 51% of HIV-1 seropositive individuals, are inadequately represented in clinical and preclinical studies, as well as in the description of HIV-1 associated neurocognitive disorders (HAND). Direct comparisons of neurocognitive decline in women and men must be made to address thi...

toxic effects of trace elements upon the hypothalamic- pituitarytesticular axis and sex hormones have been reported in recent years. it is generally considered that cdcl2 poisoning causes histopathological changes in the testicles of male rats. little attention had been drawn to the possible toxic effects of cdcl2 on the ovary and female sex hormones. the purpose of the present study was to det...

Hormones must be balanced and dynamically controlled for the Female Reproductive Tract (FRT) to function correctly during menstrual cycle, pregnancy, delivery. Gamete selection successful transfer uterus, where it implants pregnancy occurs, is supported by mucosal epithelial lining of FRT ovaries, cervix, fallopian tubes, vagina. Successful implantation placentation in humans other animals rely...

A bioassay of technical-grade 1,2-dichloroethane for possible carcinogenicity was conducted using Osborne-Mendel rats and B6C3F1 mice. 1,2-Dichloroethane in corn oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The 78-week period of chemical administration was followed by an observation period of 32 weeks for the low dose rats...

A bioassay for possible carcinogenicity of technical-grade dibromochloropropane (DBCP) was conducted using Osborne-Mendel rats and B6C3F1 mice. DBCP in corn oil was administered by gavage 5 days a week, at either of two dosages, to groups of 50 male and 50 female animals of each species. Initial dosage levels for the chronic bioassay were selected on the basis of a preliminary subchronic toxici...

It has long been known that estradiol influences synaptic plasticity in the female hippocampus. The density of dendritic spines varies during the estrous cycle and correlates positively with varying levels of estradiol in serum. In accordance, ovariectomy results in a loss of spines that can be rescued by estradiol treatment in animals, suggesting that estradiol originating from the ovaries ind...