During the healing of an experimental skin wound, epidermal cells and granulation tissue fibroblasts (myofibroblasts) develop an extensive cytoplasmic contactile apparatus. Concurrently, the proportion of epidermal cell surface occupied by gap junctions increases when compared to normal skin, and newly formed gap junctions appear between myofibroblasts; this suggests that epidermal cell migrati...

Identification of recurrent cholesteatoma and differentiation from postoperative granulation tissue is important in a patient who has undergone mastoidectomy for cholesteatoma. We describe the diffusion-weighted imaging findings and apparent diffusion coefficient values in a case of recurrent cholesteatoma. This case suggests possible differentiation of cholesteatoma from granulation tissue on ...

OBJECTIVE To study the pathogenesis of the pain of discography and the discogenic low back pain. METHODS 19 specimens of lumbar intervertebral discs from 17 patients with discogenic low back pain during posterior lumbar interbody fusion, and 12 physiologically aging discs and 10 normal control discs were collected to investigate the morphologic features and innervation containing neuropeptide...

OBJECTIVES To compare the data for histologic composition of the herniated disc material between different types of disc herniations and between patients of different age. BACKGROUND Lots of studies have investigated the histologic composition of disc herniations. Few studies have examined the presence of granulation tissue related to the type of herniations and age of the subjects. METHODS...

The ability to measure objectively wound healing is important for an effective wound management. Describing wound tissues in terms of percentages of each tissue colour is an approved clinical method of wound assessment. Wound healing is indicated by the growth of the red granulation tissue, which is rich in small blood capillaries that contain haemoglobin pigment reflecting the red colour of th...

OBJECTIVE Bacteria- and fungus-binding mesh traps and inactivates bacteria and fungus, which makes it interesting, alternative, and wound filler for negative pressure wound therapy (NPWT). The aim of this study was to compare pathogen-binding mesh, black foam, and gauze in NPWT with regard to granulation tissue formation and ingrowth of wound bed tissue in the wound filler. METHODS Wounds on ...

OBJECTIVES Vascular endothelial growth factor A (VEGF-A) is important in the angiogenic response for wound healing. This study investigated whether VEGF-A may play a role in the pathogenesis of acquired airway stenosis. METHODS Eight lesions from 5 pediatric patients with subglottic stenosis after airway reconstruction (N = 4) or prolonged intubation (N = 1) and normal laryngeal tissue from 5...

BACKGROUND Therapeutic effects of various treatment options in burn wound healing have been one of the most controversial issues in wound care. Aloe Vera is an herbal medicine, which has wound healing effects on chronic wound. The present study was carried out to examine and compare the effect of Aloe Vera gel and nitrofurazone 2% on epithelialization and granulation tissue formation with respe...