The mammalian b-globin locus is a multigenic, developmentally regulated, tissuespecific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism by which the b-globin LCR stimulates transcription of the linked b-like globin genes remains unknown. The LCR is composed of a series of 5 DNaseI hypersensitive sites (5*HSs) ...

In [1], Gu and Tian [Chuanqing Gu, Zhaolu Tian, On the HSS iteration methods for positive definite Toeplitz linear systems, J. Comput. Appl. Math. 224 (2009) 709–718] proposed the special HSS iteration methods for positive definite linear systems Ax = b with A ∈ Cn×n a complex Toeplitz matrix. But we find that the special HSS iteration methods are incorrect. Some examples are given in our paper.

This paper is concerned with a generalization of the Hermitian and skew-Hermitian (HSS) splitting iteration for solving positive definite, non-Hermitian linear systems. It is shown that the new scheme can outperform the standard HSS method in some situations and can be used as an effective preconditioner for certain linear systems in saddle point form. Numerical experiments using discretization...

Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS, also known as DRESS) are life-threatening drug hypersensitivity reactions. Previous studies on genetic predictors for SJS and HSS were focused on immune-related genes and on known, frequent polymorphisms in the genome. For the anticonvulsant carbamazepine (CBZ), genetic markers for CBZ-induced SJS and HSS have been ...

UNLABELLED We report on a 5-year-old girl who presented with the full clinical criteria of Hallermann-Streiff syndrome (HSS). Classically, overtubulation (thin and gracile) bones are the characteristic and constant features in HSS. Interestingly, our present patient manifested unusual mid-diaphyseal endosteal thickening with subsequent medullary narrowing (defective endosteal resorption). To th...

‘Hierarchical Semi-separable’ matrices (HSS matrices) form an important class of structured matrices for which matrix transformation algorithms that are linear in the number of equations (and a function of other structural parameters) can be given. In particular, a system of linear equations Ax = b can be solved with linear complexity in the size of the matrix, the overall complexity being line...

BACKGROUND The self-rating score (SRS) versus examiner rating score (ERS) in measuring helplessness in healthy study subjects (HSS) and in patients with benign breast disease (BBD) and breast cancer (BC) has not been yet compared in a prospective study. We, therefore, investigated SRS versus ERS in 115 patients. PATIENTS AND METHODS In an extension of the Kuopio Breast Cancer Study 115 women ...

PROBLEM Although efforts to integrate health systems science (HSS) topics, such as patient safety, quality improvement (QI), interprofessionalism, and population health, into health professions curricula are increasing, the rate of change has been slow. APPROACH The Teachers of Quality Academy (TQA), Brody School of Medicine at East Carolina University, was established in January 2014 with th...