Abstract Introduction: Isolated perfused heart models such as perfusion and superfusion are commonly used for mammalian heart research. However, there are several fundamental limitations in the current techniques. In perfusion model, a suitable cannula is connected to the aorta and the perfusion is retrogradely performed. But, electrode displacement is a potential unwanted event resulted fr...

A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.

In the present study, 110 fungal strains of Persian Type Culture Collection (PTCC) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The fungal strains were cultivated in a t...

(S)-(-)-N-[2-(3-Hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide (EA), a new compound isolated from the plant Selaginella pulvinata, has been identified to possess anti-proliferative effects against SK-mel-110 cells in vitro via upregulating expression of inhibitor growth family member 4. The present study aimed investigate whether EA could exert antitumor colon cancer. results reveale...

HIGHLIGHTS Streptomyces sp. nkm1 was isolated from a marine soil sample and identified using morphological molecular techniques. had the highest antifungal activity against some plant pathogenic fungi on M6 medium. On Aspergillus flavus, minimum inhibitor concentration of ethyl acetate Crude extract more effective. The GC-MS analysis revealed 26 components, with nonadecane being most important ...

objectives : this finite element method study aimed to compare the amount of stress on an isolated mandibular second premolar in two conventional reciprocal parallel interface designs of removable partial dentures (rpds) and the same rpd abutment tooth (not isolated). materials and methods: a kennedy class 1, modification 1 rpd framework was simulated on a 3d model of mandible with three differ...

Yong Chul Ju1 [email protected] Silvia Tozza2 [email protected] Michael Breuß1 [email protected] Andrés Bruhn3 [email protected] Andreas Kleefeld1 [email protected] 1 Institute for Applied Mathematics and Scientific Computing BTU Cottbus, Germany 2 Department of Mathematics Sapienza University of Rome, Italy 3 Institute for Visualization and Interactive Systems University of...

in the present study, 110 fungal strains of persian type culture collection (ptcc) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coa reductase (hmg-coa reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. the fungal strains were cultivated in a t...

Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-selective PDE inhibitor, but with differential chronotropic effect. In this in...

Abstract Background Diabetes clinical trials have shown SGLT inhibition improves cardiovascular outcomes, yet the mechanism is not fully understood. Hyperglycemia a common finding in diabetic and non-diabetic patients presenting with ACS powerful predictor of prognosis mortality. The role hyperglycemia ischemia-reperfusion injury (IRI) understood, whether Sodium Glucose Co-Transporter 1 (SGLT1)...