نتایج جستجو برای: p53 expression

تعداد نتایج: 898809  

Journal: :acta medica iranica 0
s. arbabi bidgoli b. minaee m. h. ghahremani s. n. ostad m. djamali-zavarei e. azizi

the current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. we studied the p53 and bcl-2 protein expression in esophageal carcinomas to correlate molecular alterations with clinicopathological findings. tissue samples of 37 patients with advanced esophageal carcinoma were analyzed by imm...

Azar Fani Pakdel Kamran Ghafarzadegan Kazem Anvari, Mehdi Seilanian Toosi, Mohammad Reza Ghavam Nasiri Roham Salek

Background and Objective: P53 is a suppressive gene that plays a key role in DNA repair and apoptosis. The purpose of this study was to investigate the effect of P53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (SCC) response to neoadjuvant chemoradiotherapy. Patients and Methods: In this retrospective cohort study, 44 patients with loc...

Journal: :international journal of hematology-oncology and stem cell research 0
zohreh sanaat tabriz university of medical science, tabriz, iran. monireh halimi tabriz university of medical science, tabriz, iran. morteza ghojezadeh tabriz university of medical science, tabriz, iran. amir hossein pirovi tabriz university of medical science, tabriz, iran. jalil vaez gharamaleki tabriz university of medical science, tabriz, iran. ali esfahani jamal eivazi ziae tabriz university of medical science, tabriz, iran.

introduction: gastric cancer remains the second most common cause of cancer-related deaths worldwide. in many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in ki-67, her-2/neu, p53. in this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker ki-67, surface expression of cd44, her-2/...

Fatemeh Poorhosseini, Robab Sheikhpour,

Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

Absalan F, Movahedin M Mowla SJ

Background: Experimental cryptorchidism is a common model for examining the expression and function of heat-induced spermatogenesis related genes in testis. In this study the expression of genes & proteins thatinvolved in programmed cell death after treatment of cryptorchidism was examined. Materials and Methods: To induce bilateral cryptorchid model immature mice were anesthetized and a small ...

Background: Some operating room personnel are occupationally exposed to genotoxic agents such as anesthetic gases and ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA (priming dose), which in the subsequent exposure to higher dose of those factors (challenging dose), show more resistance and sensibility.. <b...

Journal: :biomacromolecular journal 2015
alemeh heidarzadeh ali mohammad ahadi alireza panahi majid sadeghizadeh

curcumin is a natural substance with anti-cancerous properties without many disadvantages of currently-used anticancer drugs. its toxicity is significantly higher in tumor cells compared with normal cells. we hypothesized the difference of p53 function between normal and tumor cells as one of the presumable causes of this phenomenon. we knocked down the expression of p53 in normal fibroblasts u...

ژورنال: بیماری های پستان 2022

Introduction: The use of drug delivery systems can increase the effectiveness of chemotherapy and reduce its side effects in the treatment of breast cancer. This study aimed to evaluate the effect of doxorubicin-containing silk fibroin nanoparticles (NF-DOX) on P53 gene expression in breast cancer cell lines and to measure its toxicity in vitro. Methods: NF-DOX was synthesized and characterize...

Journal: :iranian journal of pharmaceutical research 0
nasrin yazdanpanahi department of biochemistry, falavarjan branch, islamic azad university, isfahan, iran mandana behbahani department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, iran, isfahan. afsaneh yektaeian department of biochemistry, falavarjan branch, islamic azad university, isfahan, iran

abstract boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in iran. the aim of this study was to evaluate the effect of the gum methanol extract of boswellia thurifera on the viability and p53 gene expression of cultured breast cancer cells. the gum methanol extract was obtained in various concentrations using the maceration method. no...

Abstract Boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in Iran. The aim of this study was to evaluate the effect of the gum methanol extract of Boswellia thurifera on the viability and P53 gene expression of cultured breast cancer cells. The gum methanol extract was obtained in various concentrations using the maceration method. No...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید