objective: antiepileptic drugs (aeds) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current aeds therapy. some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. the aim of the p...

PURPOSE Tonic seizures and the tonic phase of tonic-clonic epileptic seizures are defined as "sustained tonic" muscle contraction lasting a few seconds to minutes. Visual inspection of the surface electromyogram (EMG) during seizures contributed considerably to a better understanding and accurate diagnosis of several seizure types. However, quantitative analysis of the surface EMG during the ep...

PURPOSE This study investigated the duration of generalized tonic-clonic seizure (GTCS) and the factors that prolong GTCS duration. METHOD We retrospectively analyzed clinical data collected from a consecutive group of patients who underwent video-electroencephalography (EEG) and experienced at least one GTCS during monitoring. Each seizure was divided into seven phases. The duration of GTCS ...

Clozapine is the second-generation antipsychotic most frequently associated with seizures with risk varying from 1-5%. The seizure types are diverse, varying from generalized tonic-clonic subtype, partial, atonic or myoclonic jerks. Myoclonic and atonic subtypes are more likely to go unrecognized and have been shown to be a harbinger for further seizures of tonic-clonic variety. We report a cas...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...