Spermatogenesis is regulated by genetic and epigenetic factors. However, the genes signaling pathways mediating human spermatogenesis remain largely unknown. Here, we have for first time explored expression, function, mechanism of glutathione peroxidase 3 (GPx3) in controlling proliferation apoptosis spermatogonial stem cells (SSCs). We found that GPx3 was expressed SSCs. Notably, revealed knoc...

A growing number of reports have revealed that microRNAs (miRNAs) play critical roles in spermatogenesis. Our previous study showed that miR-762 is differentially expressed in immature and mature testes of Large White boars. Our present data shows that miR-762 directly binds the 3' untranslated region (3'UTR) of ring finger protein 4 (RNF4) and down-regulates RNF4 expression. A single nucleotid...

during hibernation period from mid october to late march, we removed testis of laudakia caucasia. based on histological and statistical analyses we obtained two phases in spermatogenesis in this lizard as follows: (a) from october to december, in which the spermatogenesis is inactive and (b) from january to march, in which the spermatogenesis is active. spermatogenesis during late hibernation o...

Effect of ginger (Zingiber officinale R.) on metiram-inhibited spermatogenesis and induced apoptosis in albino miceSaber A. Sakr, Gamal M. Badawy

I investigated the seasonal testicular histology and acystic lobular spermatogenesis in Western Lesser Siren, Siren intermedia nettingi, from periodic sampling of this salamander over a span 21 yr (1994-2015) northeastern Arkansas. My results include following general findings: 1) largest lobules occurred primarily January-February during spermiogenesis spermatozoa maturation; 2) regression spe...

BACKGROUND Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier gene...

We showed previously that testosterone (T) alone could induce spermatogenesis and produce normally fertile spermatozoa in the absence of circulating gonadotropins. These studies used the hpg mouse, which is characterized by a congenital gonadotrophin deficiency due to a major deletion in the GnRH gene. Administering T by a subdermal implant of a SILASTIC brand tube impregnated with crystalline ...

objective: animal model studies have shown that msy2 and jhdm2a genes have an important role in spermatogenesis process and fertility of male mice. but the potential role of these genes in human spermatogenesis and fertility is not known yet. therefore, we evaluated expression ratios of these genes in testis tissues of men with normal and impaired spermatogenesis. materials and methods: in this...

Several case-control studies have investigated the effect of CAG repeat length variation in the POLG gene on male fertility and semen quality. Some described an association between the homozygous not10 CAG-repeat genotype and male subfertility and/or reduced semen quality, whereas others did not. The aim of our study was to investigate whether the not10/not10 variant is associated with spermato...