Cyclosporin A (CS-A), selectively inhibited cellular immunity, delayed the skin graft-induced rejection of corneal allografts in rabbits when administered subconjunctivally in the dose of 3 mg/kg/day or in the form of 5% water-soluble drops five times daily for 28 days. The subconjunctival application of CS-A was irritating, whereas the topical instillation of the water-soluble preparation was ...

An online survey of members of the American Society of Cataract and Refractive Surgery indicated a strong preference for preoperative and postoperative topical antibiotic prophylaxis, with most surgeons favoring latest generation topical fluoroquinolones. A significant percentage of surgeons reported being concerned about the risks of homemade intracameral antibiotic preparations, and there was...

Resorcinol, also known as resorcin (1,3-dihydroxybenzene; CAS no. 108-46-3), is an important ingredient of Castellani’s paint solution, an antifungal preparation that is commonly used in daily dermatological clinical practice. Apart from its use in hair dyes, resorcinol is also used in several other topical preparations, because of its antipruritic, keratolytic and antimycotic properties. Sodiu...

In this review article, the anesthetic challenges and management of patient posted for glaucoma surgery are discussed. The various physiological and pharmacological factors that influence the level of intraocular pressure in the perioperative period are highlighted. The syndromes of anesthetic implications in childhood glaucoma, the systemic effects of topical antiglaucoma medications, preparat...

Invasive fungal infections can be devastating, especially in immunocompromized patients. Oral administration of fluconazole (FLZ) often produces gastric irritation, heart-burn, vomiting and sometimes patient can develop ulceration resulting in a less patient compliance with long term therapy. The aim of the present study was to formulate topical microsponge-based delivery system containing FLZ ...

The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for ...

Valdecoxib, a selective COX-2 inhibitor, produces serious side effects when given orally. This has led to its withdrawal. Topical application of valdecoxib was formulated and evaluated for its efficacy and safety. Standard procedures were followed and male Wistar albino rats were used to test the anti-inflammatory effect and effect in hyperalgesic conditions. Ointments, creams, and gels contain...

To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group ...