Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. At P12, synaptic responses were undetectable. Only 2 days later in life (P14), ...

introduction: it is believed that locus coeruleus (lc) influences the sensory information processing. however, its role in cortical surround inhibitory mechanism is not understood. in this experiment, using controlled mechanical displacement of whiskers we investigated the effect of phasic electrical stimulation of lc on response of layer v barrel cortical neurons in anesthetized rat. methods: ...

Sensory experience drives robust plasticity of sensory maps in cerebral cortex, but the role of inhibitory circuits in this process is not fully understood. We show that classical deprivation-induced whisker map plasticity in layer 2/3 (L2/3) of rat somatosensory (S1) cortex involves robust weakening of L4-L2/3 feedforward inhibition. This weakening was caused by reduced L4 excitation onto L2/3...

Biodynamic feedthrough (BDFT) refers to a phenomenon where accelerations cause involuntary limb motions which, when coupled to a control device, can result in unintentional control inputs. Biodynamic feedthrough can occur in many different vehicles and under various conditions, which makes it highly relevant to study its mechanisms. In this paper the possible biodynamic feedthrough mitigation t...

Given any finite simplicial complex ∆, we show how to construct from a colouring χ of ∆ a new simplicial complex ∆χ that is balanced and vertex decomposable. In addition, the h-vector of ∆χ is precisely the f -vector of ∆. Our construction generalizes the “whiskering” construction of Villarreal, and Cook and Nagel. We also reverse this construction to prove a special case of a conjecture of Coo...

..........................................................................................ii ACKNOWLEDGEMENTS.........................................................................iv TABLE OF CONTENTS............................................................................v LIST OF FIGURES..................................................................................vii CHAPTER I: INTRO...

introduction: in the present study the effect of nucleus basalis of meynert (nbm) destruction on the temporal characteristics of response integration evoked by multiple whisker stimulations in rat barrel cortex was studied. material and methods: wistar male rats weighing 250-350 g were used. the animals were randomly distributed into two groups: in the first group bilateral nbm lesions was indu...