BACKGROUND Conjugating immunostimulatory sequences of DNA to specific allergens offers a new approach to allergen immunotherapy that reduces acute allergic responses. METHODS We conducted a randomized, double-blind, placebo-controlled phase 2 trial of a vaccine consisting of Amb a 1, a ragweed-pollen antigen, conjugated to a phosphorothioate oligodeoxyribonucleotide immunostimulatory sequence...

Akaike's information theoretic criterion for model discrimination (AIC) is often stated to "overfit", i.e., it selects models with a higher dimension than the dimension of the model that generated the data. However, with experimental pharmacokinetic data it may not be possible to identify the correct model, because of the complexity of the processes governing drug disposition. Instead of trying...

The Akaike Information Criterion (AIC) is often used as a measure of model accuracy. The ∆AIC statistic is defined by the difference between AIC values for two nested models. The ∆AIC statistic corresponding to a particular change detection problem has been shown to detect extremely small changes in a dynamic system as compared with traditional change detection monitoring procedures. In this pa...

Bayesians often reject the Akaike Information Criterion (AIC) because it introduces ideas that do not fit into their philosophy of statistical inference. Here we show that a difference in the AIC scores that two models receive is evidence that they differ in their degrees of predictive accuracy, where evidence is understood in terms of the Law of Likelihood. Since the Law of Likelihood is a cen...

Akaike's information theoretic criterion for model discrimination (AIC) is often stated to "overfit", i.e., it selects models with a higher dimension than the dimension of the model that generated the data. However, with experimental pharmacokinetic data it may not be possible to identify the correct model, because of the complexity of the processes governing drug disposition. Instead of trying...

BACKGROUND Stress-related mental disorders (SRMD) are common and costly. Rehabilitation strategies, including pharmacotherapy, may be complicated to evaluate. Previous research has indicated increased quality of life and self-rated health for SRMD patients that receive a combination of conventional and complementary therapies, i.e. integrative care. The aim of this retrospective registry study ...