Neurodegenerative disorders and brain damage are initiated by excessive production of reactive oxygen species (ROS), which leads to tissue injury, cellular death and inflammation. In cellular anti-oxidant systems, heme oxygenase-1 (HO-1) is an oxidative-sensor protein induced by ROS generation or carbon monoxide (CO) release. CO releasing molecules (CORMs), including CORM-3, exert anti-oxidant ...

abstract in order to investigate the effect of biofertilizer, chemical fertilizer and plant density on yield and corm criteria of saffron, an experiment was conducted as complete randomized block design in a factorial arrangement with three replications under field condition in agricultural college, ferdowsi university of mashhad during 3 years of 2007,2008,2009. treatments included nitroxin bi...

Salinity and water stress reduces the ability of plant to take up water and decrease growth rate, photosynthesis rate (An) and stomatal conductance (gs) of plants. In this study, effects of deficit irrigation with different salinity levels and planting method (in-furrow and on-ridge) as strategies for coping with water and salinity stress on physiologic properties of rapeseed was investigat...

background & aim: saffron (crocus sativus l.) formerly was important in turkey. saffron cultivation has been decreased and it is now only cultivated in three villages in this country. it is triploid and exclusively propagated in a vegetative way by corms. in turkey, saffron is traditionally planted by placing corms in rows randomly without grading or sorting; which results in placement of c...

faba bean is one of the proper crops for cultivation in guilan climate conditions in rotation with rice. one of the limiting factors in development of cultivating this plant is late maturity and synchronizing of its ripening with rice transplanting. to investigate the effect of planting date, timing and consumption rate of paraquat herbicide on the ripening, grain yield and some of the agronomi...

Carbon monoxide (CO) produced by heme oxygenase (HO)-1 and HO-2 or released from the CO-donor, tricarbonyldichlororuthenium (II) dimer (CORM-2) causes vasodilation, with unknown efficacy against stress-induced gastric lesions. We studied whether pretreatment with CORM-2 (0.1-10 mg/kg oral gavage (i.g.)), RuCl₃ (1 mg/kg i.g.), zinc protoporphyrin IX (ZnPP) (10 mg/kg intraperitoneally (i.p.)), he...

AIMS Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy. METHODS AND RESULTS Mice were fed...