PCR analysis of herpes simplex virus (HSV) genome replication and productive-cycle transcription was used to examine the role of the cornea in the latency-associated transcript (LAT)-mediated reactivation of HSV type 1 (HSV-1) in the rabbit eye model. The reduced relative reactivation frequency of 17 delta Pst (a LAT- virus) compared to those of wild-type and LAT+ rescuants correlated with redu...

In the paper we develop multi-class classification of Fermi-LAT gamma-ray sources using machine learning with hierarchical determination classes. One main challenges in is that size some classes relatively small, for example less than 10 associated belonging to a class. propose structure This enables us have control over and compare performance different numbers particular, class probabilities ...

The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutant dLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+ strains (G.-C. Perng,...

BACKGROUND Most research asks whether or not cohabitation has come to rival marriage. Little is known about the meaning of living apart together (LAT) relationships, and whether LAT is an alternative to marriage and cohabitation or a dating relationship. OBJECTIVE We examine across Europe: (1) the prevalence of LAT, (2) the reasons for LAT, and (3) the correlates of (a) LAT relationships vis-...

PURPOSE To determine if low doses of topical latrunculin B (LAT-B) will increase outflow facility and decrease intraocular pressure (IOP) without adversely affecting the cornea, and inhibit miotic and accommodative responses to pilocarpine, in ocular normotensive monkeys. METHODS Intraocular pressure was measured by Goldmann tonometry before and after one and nine dose(s) of 0.005% and 0.01% ...

The linker for activation of T cells (LAT), the linker for activation of B cells (LAB), and the linker for activation of X cells (LAX) form a family of transmembrane adaptor proteins widely expressed in lymphocytes. These scaffolding proteins have multiple binding motifs that, when phosphorylated, bind the SH2 domain of the cytosolic adaptor Grb2. Thus, the valence of LAT, LAB and LAX for Grb2 ...

In its first three months of operations, the Fermi Gamma-Ray Observatory has detected approximately one quarter of the radio-flux-limited MOJAVE sample of bright flat-spectrum active galactic nuclei (AGNs) at energies above 100 MeV. We have investigated the apparent parsec-scale jet speeds of 26 MOJAVE AGNs measured by the Very Long Baseline Array (VLBA) that are in the LAT bright AGN sample (L...