To Zagros, my lovely husband, For his unending love and sacrifices. To Mohsen, my dear brother, Who always besides me. To you, as a reader…. This work would not have been completed without the help and support of many kind people around me, to only some of whom it is possible to give particular mention here. First and foremost, I would like to express my deepest gratitude to my thesis directors...

Loss of TGF-b type II receptor (TbRII, encoded by Tgfbr2) expression in the prostate stroma contributes to prostate cancer initiation, progression, and invasion.We evaluated whether TbRII loss also affected prostate cancer bone metastatic growth. Immunohistologic analysis revealed that TbRII expression was lost in cancer-associated fibroblasts in human prostate cancer bone metastatic tissues. W...

In a greenhouse study, decontamination capacity of the species Polypogon monspoliensis was investigatedfor detoxification of petroleum-polluted soils caused by sewage and waste materials of Tehran Petroleum Refinery. For this purpose, the amount of total oil and grease before and 45 days after transplanting one-month-old seedlings in the soils of five different treatments were measured. Polluti...

FaRhaD KhoSRaVI, BEnJamIn KIng, SESh RaI, goEtz KloEcKER, ERIc WIcKStRom, anD BalaJI PanchaPaKESan Nanotube Devices for Digital Profiling CirCulating tumor Cells (CtCs) were f irst discovered in 1869 in the blood of patients suffering from metastatic disease by an australian physician, thomas ashworth, using optical microscopy [1]. the current understanding is that these CtCs mediate the spread...

I am writing in response to the article, “A quantitative and qualitative study of rat testis following administration of methadone and buprenorphine” by Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb & Farhad Kohan in Volume 1(1): 14-17, 2012 (1). This article is addresses an important subject, that of hypogonadism and other changes in seminiferous tubules and testis after administration of metha...