Cancer is the major cause of death in the world and the rate of mortality is higher in developed countries. Therefore, lifestyle could be effective in promoting the cancer. The pancreatic tumors, are 8th cause of mortality due to cancer, which have several types, among them ductal adenocarcinoma is the most common and includes 85% of cases. Since, it is almost impossible to diagnosis the tumor ...

Cancer stem cells are believed to be responsible for the cancer-initiating step and resistance to chemotherapy drugs. Studies have shown that cancer stem cells are silent and have no metabolic activity. The main reasons behind tumors resistant to therapies are lack of activity of cancer stem cells and division of cancer cells. This cell population, like normal stem cells, is capable of self-ren...

Background and Objective: Breast cancer is a genetic and chronic inflammatory disease with an increasing incidence among Iranian women. Researchers have shown that regular exercise is presumed to have prophylactic effect and adjuvant therapy in inhibition of tumor growth. So the aim of this study was to assess the effect of endurance training on serum TNF-α in breast cancer bearing mice. Materi...

Backgrounds: SIRT1 plays an important role in many physiological processes, including metabolism, neuronal protection, senecence and inflammatory, by staging histones and multiple transcription factors. However, the complex mechanisms of SIRT1 signaling in tumors are not yet fully understood, as it acts as both an oncogen and a tumor suppressor. On the other hand, it has been shown that the Lnc...

Background and purpose: Breast cancer is the most common cause of cancer-specific mortality among women worldwide. This study aimed at investigating the epidemiological, clinical, and pathological characteristics of breast cancer among patients attending Baghban Clinic in Sari. Materials and methods: The patients’ records (2008-2014) were used and data including age, gender, marital st...

Introduction: Breast cancer remains the prominent cause of mortality in women. Several biomarkers are used to evaluation the response and targeting to therapy. Tumor suppressor candidate 1 (TUSC1) gene was newly identified as a probable tumor suppressor in human cancers. Nevertheless, the expression and potential function of TUSC1 in breast cancer stay undecided. Therefore, this study aimed the...