objective(s): vinblastine is antimitotic, anticancer medicine that disturbs normal microtubule formation and favours depolymerisation. structural study and finding the active site of vinblastine are the targets of this research.   materials and methods: vinblastine was optimized in vacuum and then in different solvents by density functional theory (dft) method. nuclear magnetic resonance (nmr) ...

in this study, we present the work on the physicochemical interaction between the anti-cancer alkaloidberberine (brb) and dna with the purpose of designing drugs that interact more with dna. molecularmodeling on the complex formed between berberine and dna presented that this complex was undeniablyfully able of participating in the formation of a stable intercalation site. besides, the molecula...

in this research, we report the results of dft calculations using xc-hybrid functional, b3lyp and employ nbo interpretation to investigate the stereoelectronic effects. electrostatic and steric impacts on the conformational properties of 1,2-difluorodiazene (1), 1,2-dichlorodiazene (2) and 1,2-dibromodiazene (3) are also studied. factors determining the thermodynamically stable molecular struct...

conclusions according to the results, the iranian public health centers preparedness against disasters before, during and after accidents were in safety level 4 from 10, which was undesirable. results risk rate, functional, non-structural and structural preparedness and final safety level were 58.62%, 51.48%, 54.82%, 33.97%, and 43.72%, respectively. background ahvaz metropolitan as an industri...

abstract background: several studies have examined the reflex response of ankle musculature to sudden inversion in noninjured and injured subjects. to date, there have been no studies to determine the effect of versatile degrees & conditions of perturbation on the ankle musculature latency. the purpose of this study was to measure and determine whether there was a difference in ankle musculatur...

background : chronic constipation is a common problem worldwide that negatively impacts quality of life. because of the effects of psychological and cultural factors on the function of the bowel tract and the vast variety of ethnicities and diet among the iranian people, the present study describes the occurrence of constipation and its associated factors in kerman, the largest city in southeas...

background and objective: oxidative stress, due to free radicals, brings injury to the body by attacking large molecules and cell organs, and is the main reason of many diseases. fermentation of foods containing large amount of proteins such as milk by special species of lactic acid bacteria is a potential way in enhancement of the antioxidative activity of foods. this study aimed at evaluating...

sensitivity analysis with respect to the functional forms provides estimates of the uncertainties involved in choosing a specific functional structure. this is vital in cge modeling where it is conventional to take elasticities from other studies. in the present study, the robustness of model results with respect to the functional form is checked. in one scenario, the production function is rep...