Conclusions LNMAC histopathology reveals a necrotic core (amorphous eosinophilic material) and surrounding inflammatory rim (macrophage and lymphocytic infiltration) with zonal calcification. By MRI this zone of cellular inflammation and edema manifests as the zone of peripheral hyperenhancement on the PSIR, HASTE, and IR TURBOFLASH sequences. Most benign or malignant cardiac tumors show high T...

Background The heterogeneous peri-infarction zone surrounding the core infarct with cardiac magnetic resonance imaging (CMR) late gadolinium enhancement (LGE) has been linked to all-cause mortality in patients with coronary artery disease. Previously, the heterogeneity of fibrotic areas has been analyzed by threshold algorithms. We hypothesized that the heterogeneous peri-infarction zone is rel...

This paper presents a quantitative modeling for delineating alteration zones in the hypogene zone of the Miduk porphyry copper deposit (SE Iran) based on the core drilling data. The main goal of this work was to apply the Ordinary Kriging (OK), Artificial Neural Networks (ANNs), and Concentration-Volume (C-V) fractal modelings on Cu grades to separate different alteration zones. Anisotropy was ...

Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a presynaptic nerve terminal. In this review, I discuss the molecular composition and function of the active zone. Active zones are composed of an evolutionarily conserved protein complex containing as core constituents RIM, Munc13, RIM-BP, α-liprin, and ELKS proteins. This complex docks and primes synaptic vesi...

The active zone is a specialized region of the presynaptic plasma membrane where synaptic vesicles dock and fuse. In this study, we have investigated the cellular mechanism underlying the transport and recruitment of the active zone protein Piccolo into nascent synapses. Our results show that Piccolo is transported to nascent synapses on an approximately 80 nm dense core granulated vesicle toge...