In depth interaction studies between calf thymus deoxyribonucleic acid (CT-DNA) and a series of four structurally relative palladium(II) complexes [Pd(en)(HB)](NO3)2 (a-d), where en is ethylenediamine and heterocyclic base (HB) is 2,2'-bipyridine (bpy, a); 1,10-phenanthroline (phen, b); dipyridoquinoxaline (dpq, c) and dipyridophenazine (dppz, d) (Figure 1), were performed. These studies have b...

background: recent research on several dna fragments covering open reading frames (orf) 1-37 shows a new genetic marker in orf 6 which is specific for differentiating wild-type varicella-zoster virus (vzv) strains from oka varicella vaccine strain. on the other hand, herpes simplex virus (hsv) genome analysis by restriction enzymes is used to differentiate types one and two of the virus and eve...

Abstract We investigated the interaction of As(III) with As(III)-binding DNA aptamers (Ars-3). The binding Ars-3 to was using an sequence and a few control sequences. As result, we conclude that cannot bind can adsorb onto gold nanoparticles selectivity. However, concentration could be determined by simple analysis method Ars-3, measured As(V) concentrations separately in As(III)/As(V) mixed sa...

A series of nonsymmetrical 2,3-diaminoquinoxaline derivatives prepared straight-forwardly by the C-N coupling between chloro-quinoxaline (2,3-DCQ) and various amino substrates. Synthesized products (4a-z) with excellent purity (1HNMR) without performing flash column chromatography purification. Investigated antibacterial activity selected nine compounds against Gram-positive, Gram-negative bact...

Abstract Machine learning approaches have been applied to identify transcription factor (TF)–DNA interaction important for gene regulation and expression. However, due the enormous search space of genome, it is challenging build models capable surveying entire reference genomes, especially in species where were not trained. In this study, we surveyed a variety methods classification epigenomics...

Understanding DNA–ligand binding interactions requires ligand screening, crystallization, and structure determination. In order to obtain insights into the amyloid peptide precursor (APP) gene–Thioflavin T (ThT) interaction, single crystals of two DNA sequences 5′-GCCCACCACGGC-3′ (PDB 8ASK) d(CCGGGGTACCCCGG)2 8ASH) were grown in presence ThT or its analogue 2-((4-(dimethylamino)benzylidene)amin...

In depth interaction studies between calf thymus deoxyribonucleic acid (CT-DNA) and a series of four structurally relative palladium(II) complexes [Pd(en)(HB)](NO3)2 (a-d), where en is ethylenediamine and heterocyclic base (HB) is 2,2'-bipyridine (bpy, a); 1,10-phenanthroline (phen, b); dipyridoquinoxaline (dpq, c) and dipyridophenazine (dppz, d) (Figure 1), were performed. These studies have b...