Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney failure and visual impairment. Alpha-mangostin is a xanthone found in mangosteen fruit with protective effects in met...

The vascular permeability of the endothelium is finely controlled by endothelial (VE)-cadherin-mediated cell–cell junctions. In majority normal adult tissues, cells in blood vessels maintain at a relatively low level, while response to inflammation, they limit barrier function induce plasma leakage and extravasation immune as defense mechanism. Thus, dynamic but also simultaneously tight regula...

Most common tumors of the spleen are hematologic and lymphoid malignancies. Non-lymphoid and non-hematologic tumors of the spleen are very rare, the most common of which are vascular tumors. This group of tumors in the spleen is composed of heterogeneous tumors such as hemangioma, angioendothelioma (AE), littoral cell angioma, and angiosarcoma. There are several histologic forms of AE such as e...

background: lung cancer ranks among the most common and most lethal malignancies worldwide. once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. bone, liver, adrenals, and brain are the most frequent sites of the distant disease. in this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa.case presentation...

1. department of pathology, burdwan medical college, burdwan, west bengal, india 2. department of pathology, bankura sammilani medical college, bankura, west bengal, india                   corresponding author: nirmalya chakrabarti, md; tel: (+91) 9477882332 email: [email protected] received: 06 july 2014 accepted: 03 feb. 2015 iran j cancer prev. 2015; 2:129-33.     abstract among...

epithelioid hemangioendothelioma (ehe) is a rare neoplasm of vascular origin which arises preferentially in soft tissue and bone, and rarely in the liver. its vascular nature is confirmed by positive staining for factor viii-related antigen and other endothelial cell markers (cd31, cd34) in addition to the pathologic characteristics of well-developed basal lamina, pinocytotic vesicles, and, mor...

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...