A stable GS115 Pichia pastoris recombinant strain was constructed to secrete a truncated form of the human alpha(1,3/4) fucosyltransferase (amino acids 45-361). Enzyme production resulted from a secretory pathway based on the pre-pro- alpha mating factor signal sequence of the yeast Saccharomyces cerevisiae . Following its transit through the Golgi apparatus, the enzyme accumulated in the perip...

This paper is concerned with the development of a high-resolution and control-friendly optimization framework in enclosed environments that helps improve thermal comfort, indoor air quality (IAQ), and energy costs of heating, ventilation and air conditioning (HVAC) system simultaneously. A computational fluid dynamics (CFD)-based optimization method which couples algorithms implemented in Matla...

A fast and accurate method for detecting the collisions of convex polyhedra in a graphical simulation environment based on a newly developed method of distance estimate is presented. By the simultaneous use of the enclosing and the enclosed ellipsoids of convex polyhedra, potential collisions can be detected more accurate than those methods using only bounding volume for object representation, ...

Mobile robots that consist of a mobile platform with one or many manipulators mounted on it are of great interest in a number of applications. Combination of platform and manipulator causes robot operates in extended work space. The analysis of these systems includes kinematics redundancy that makes more complicated problem. However, it gives more feasibility to robotic systems because of the e...

When continuous 3D shapes or enclosed structures, such as solid objects or skeletons, are mapped onto a 2D screen, simplifications such as hulls and wire frames are suitable visualization tools, because most or all of the information is concentrated along discontinuities that occupy only a small proportion of the space. Visualizing a colour space is more difficult. Colour spaces are three-dimen...

It has been suggested that young children can only reorient, locating a target object, when the geometry of an enclosed space provides distinctive shape information [e.g., Hermer, L., & Spelke, E. (1994). A geometric process for spatial reorientation in young children. Nature, 370, 57-59]. Recently, however, young children were shown to specify location in a square-shaped space, where geometry ...

Common geometric models for proteins and other molecules are the space filling diagram, the solvent accessible surface, and the molecular surface. We descnbe software that compules metric properties of these models, including volume and surface area. It also measures voids or empty space enclosed by the protein, and it keeps track of surface area contributions of individual atoms. The software ...