Genotyping by sequencing allows for large-scale genetic analyses in plant species with no reference genome, but sets the challenge of sound inference in presence of uncertain genotypes. We report an imputation-based genome-wide association study (GWAS) in reed canarygrass (Phalaris arundinacea L., Phalaris caesia Nees), a cool-season grass species with potential as a biofuel crop. Our study inv...

BACKGROUND With the beginning of the era of genome-wide association studies methods to obtain 'in silico' genotypes have gained importance. In this context, an evaluation of genome-wide power levels of current marker panels and the power gain achievable with imputed genotypes are of high interest. METHODS Power for single-marker analysis of imputed genotypes is evaluated via a simulation stud...

Tuber quality is the subject of great interest among processing industry and consumers worldwide. Being a polygenic trait, its enhancement requires systematic understanding their genetic complexity. Molecular genetics offered valuable solutions to challenging endeavours slow gains in conventional potato breeding. With advent linkage maps, molecular markers availability next-generation sequencin...

Prophet of POU1F1 (PROP1) plays direct or indirect important roles in the morphogenesis of pituitary gonadotropes as well as lactotropes, somatotropes and caudomedial thyrotropes. It also controls the expression of growth hormone, prolactin and thyrotropin subunits through regulatory PIT1 factor. These hormones have important influences on production traits in most animal species including the ...

Development of the infant small intestine is influenced by bacterial colonization. To promote establishment of optimal microbial communities in preterm infants, knowledge of the beneficial functions of the early gut microbiota on intestinal development is needed. The purpose of this study was to investigate the impact of early preterm infant microbiota on host gut development using a gnotobioti...

BACKGROUND Recently, we reported a reduced retinal contrast gain in unmedicated and medicated patients with major depression. AIMS To analyse whether the contrast gain normalises after successful antidepressive therapy by recording the pattern electroretinogram (PERG) in healthy controls and patients with depression before and after antidepressive therapy. METHOD Fourteen patients diagnosed...

Current risk stratification schemas for medulloblastoma, based on combinations of clinical variables and histotype, fail to accurately identify particularly good- and poor-risk tumors. Attempts have been made to improve discriminatory power by combining clinical variables with cytogenetic data. We report here a pooled analysis of all previous reports of chromosomal copy number related to surviv...

What are the technologies that will transform business and drive the research agenda for the IS field in the years to come? Which innovations, platforms, and paradigms will become dominant, and which others will ultimately pass into obscurity? In this panel discussion, we will seek answers to these questions from those with a unique and unmatched perspective. The leaders who have witnessed the ...

Almost everyone knows that the inner angles of a triangle sum to 180o. But if you ask the typical mathematician how to sum the solid inner angles over the vertices of a tetrahedron, you are likely to receive a blank stare or a mystified shrug. In some cases you may be directed to the Gram-Euler relations for higher dimensional polytopes [3, 4, 6, 7], a 19th century result unjustly consigned to ...