Objective(s): The primary cytotoxic effects of anticancer drugs like idarubicin, a chemotherapeutic agent, are not limited to neoplastic cells; they also produce similar effects in normal cells. In this study, we hypothesized that the combination of idarubicin-bromelain could make cancer cells more susceptible to cytotoxicity and genotoxicity.Material...

Titanium dioxide (TiO<sub>2</sub>) was used in various applications a wide range of products including food, cosmetics and photocatalyst. General toxicity studies titanium dioxide, GST (Green Sludge Titanium) have been investigated several reports, whereas concerning mutagenicity genotoxicity not elucidated. Herein, we the potential by genetic toxicology testing. The bacterial rever...

Ever since the introduction of the Salmonella typhimurium mammalian microsome mutagenicity assay (the 'Ames test') over three decades ago, there has been a constant development of additional genotoxicity assays based upon the use of genetically engineered microorganisms. Such assays rely either on reversion principles similar to those of the Ames test, or on promoter-reporter fusions that gener...

Hospital effluents are serious problems in developing countries like Brazil, and when not treated adequately, can cause mutagenic effects on live organisms. Biomonitors, like Allium cepa L., which is one of the most used plant species when monitoring effluent genotoxicity, have been used to alert the world population about environmental contamination and genotoxic chemical emissions. The Allium...

A 14-day subchronic genotoxicity of Nimesulide was evaluated by employing mouse bone marrow chromosomal aberration test. The Nimesulide administered orally for 2 weeks at the rate of 1.5, 2.5, 5 mg/kg body weight in swiss albino mice. The results show decreased mitotic activity in all groups of Nimesulide treatments. Similar results concerning the chromosomal aberrations revealed in all treated...

Ever since the introduction of the Salmonella typhimurium mammalian microsome mutagenicity assay (the Ames test ) over three decades ago, there has been a constant development of additional genotoxicity assays based upon the use of genetically engineered microorganisms. Such assays rely either on reversion principles similar to those of the Ames test or on promoter–reporter fusions that generat...

Ethyl methanesulfonate is a synthetic compound widely used as a mutagen, teratogen and brain carcinogen and as a research chemical. While, the toxicity and carcinogenicity of ethyl methanesulfonate on humans and animals have been studied, less is known about its genotoxicity to plants. In this study, the genotoxic effects of ethyl methanesulfonate were investigated with growing chilli seedlings...

Garcinia mangostana, popularly known as "mangosteen fruit," originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia. Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing. We, therefore, evaluated genotoxicity/mutagenicity of hydroethanolic mangosteen ex...

Background & Objective: Micronucleus assay of buccal mucosa cells is a simple bio- monitoring method for diagnosing the genetic damages of toxic agents. The aim was to study the genotox...