This work describes the syntheses and antitumoral properties of five prenyl compounds from which antiproliferative activities were predicted by using the TOPS-MODE approach, a computational method for drug design. The syntheses of 2-(3-methylbut-2-enyloxy)acetophenone (2), 2-hydroxy-5-(3-methylbut-2-enyl)acetophenone (3), 2-hydroxy-3-(1,1-dimethylallyl)acetophenone (4), and 5-(3-methylbut-2-eny...

In Calabi-Yau fourfold compactifications of M-theory with flux, we investigate the possibility of partial supersymmetry breaking in the three-dimensional effective theory. To this end, we place the effective theory in the framework of general N = 2 gauged supergravities, in the special case where only translational symmetries are gauged. This allows us to extract supersymmetry-breaking conditio...

Superstitions can be understood as a way of fixing beliefs – in the face of an ongoing lack of control – by involving effectively untestable explanations. The explanations are untestable only in part due to their content: related social attitudes and available empirical capabilities also play a vital role. Importantly, untestability does not entail the lack of meaning but, rather, frees the mea...

let $k$ be a field of characteristic$p>0$, $k[[x]]$, the ring of formal power series over $ k$,$k((x))$, the quotient field of $ k[[x]]$, and $ k(x)$ the fieldof rational functions over $k$. we shall give somecharacterizations of an algebraic function $fin k((x))$ over $k$.let $l$ be a field of characteristic zero. the power series $finl[[x]]$ is called differentially algebraic, if it satisfies...

A reflection on the scientific behavior of adherents of conventional medicine toward one form of alternative medicine-homeopathy-teaches us that physicians do reject seemingly solid evidence because it is not compatible with theory. Further reflection, however, shows that physicians do the same within conventional medical science: Sometimes they discard a theory because of new facts, but at oth...

Selective C-formyl-ation of 8,9,10,11-tetra-hydro-pyrido[2',3':4,5]pyrimido[1,2-a]-azepin-5(7H)-one has been studied for the first time. It was revealed that formyl-ation proceeds by the formation of an inter-mediate salt, which due to the re-amination process on treatment with aqueous ammonia transformed into the corresponding (E)-11-(amino-methyl-ene)-8,9,10,11-tetra-hydro-pyrido[2',3':4,5]-p...

A number of chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in NaOH solution in ethanol. These chalcones were immediately reacted with urea, thiourea and guanidine hydrochloride in presence of concentrated hydrochloric acid as reagent to obtain the corresponding hydroxy, thio and amino pyrimidines. The synthesized he...