OBJECTIVES To assess the usefulness of the phosphodiesterase type 5 inhibitors (PDE5-Is) in the treatment of premature ejaculation (PE) and to describe possible mechanisms to explain their effect. METHODS A MedLine search was performed for peer-reviewed articles on the role of PDE5-Is in managing PE. No meta-analysis method was used. RESULTS Five manuscripts that examined the efficacy of PD...

OBJECTIVE To investigate the effect of a 5mg daily tadalafil treatment on the ejaculation time, erectile function and lower urinary tract symptoms (LUTS) in patients with erectile dysfunction. MATERIALS AND METHODS A total of 60 patients diagnosed with erectile dysfunction were retrospectively evaluated using the international index of erectile function questionnaire-5 (IIEF-5), intravaginal ...

objective: we conducted a double-blind, placebo-controlled study to determine the efficacy of an herbal sexual supplement (vigrx) on premature ejaculation (pe). method: a randomized double blind study was conducted on a fixed dose of herbal vigrx at roozbeh psychiatry hospital, tehran university of medical sciences. the sample consisted of 85 married patients diagnosed with primary pe according...

The therapeutic armamentarium currently available for the treatment of premature ejaculation (PE) is not highly satisfactory. However, phytotherapeutics appear to be an interesting option for PE management. The present study aimed to evaluate the tolerability and efficacy of a phytotherapeutic combination of Rhodiola rosea, folic acid, biotin and zinc (EndEP®) in the treatment of patients affec...

PURPOSE Nonresponse to any selective serotonin reuptake inhibitor (SSRI) treatment is rare. In this study, we aimed to investigate ejaculation delay nonresponse to paroxetine treatment in men with lifelong premature ejaculation (PE) who were also known to be nonresponders to other SSRIs. MATERIALS AND METHODS Five males with lifelong PE who were known nonresponders to paroxetine and other ser...

Patients 48 heterosexual men (mean age 39 y) who had lifelong rapid ejaculation and a stable relationship with a female partner. Rapid ejaculation was defined as an intravaginal ejaculation latency time (IELT) of <1 minute. Exclusion criteria included erectile dysfunction, alcohol or substance abuse, mental disorders, physical illnesses, and concomitant medications. 83% of patients completed th...

Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse...

This study aims to assess the efficacy and safety of sildenafil therapy compared with other agents in patients with premature ejaculation (PE) but without erectile dysfunction (ED). Systematically literature search was performed using PubMed, EMBASE, Medline, Science Direct/Elsevier, CNKI, and the Cochrane Library. The mean difference (MD) or relative risk (RR) and 95% confidence intervals (CI)...