angiotensin ii, the main component of the renin-angiotensin system, is associated with cardiovascular diseases such as hypertension, vascular remodeling and inflammation. remodeling process results from dysregulation of matrix metalloproteinases (mmps) and their tissue inhibitors (timps). mmps are considered as important target genes for angiotensin ii. the aim of this study was to determine th...

Klasa II je jedan od najčešćih ortodontskih problema i javlja se kod gotovo trećine populacije. Shodno tome postoji čitav niz terapijskih pristupa u terpiji skeletene anomalije klase II naročito kod pacijenata koji još nalaze u fazi rasta i razvoja. Na Svučilištu Federico II u Napulju razvijen je jednostavan pristup ovom obliku terapije. Prvi korak je postavljanje dijagnoze što uključuje kefalo...

In inclined U-notches, the mixed mode (I + II) loading occurs and the mode ratio can be increased by varying the notch angle. In this paper, the effect of the inclined U-notch geometry, i.e. the notch depth, the notch angle, the notch root radius, and the position of the notch with respect to supports, on the mode ratio (KII/KI) have been studied. Three-point bending and plane strain condition ...

Preliminary studies have shown that endothelial-monocyte-activating polypeptide-II (EMAP-II) induces autophagy and inhibits the viability of glioma cells via an unknown molecular mechanism. This study explored the possible mechanisms associated with EMAP-II-induced autophagy in glioma cells by regulation of the expression of microRNA-20a (miR-20a). EMAP-II effectively inhibited the viability, m...

The impact on U(VI) adsorbed to lepidocrocite (γ-FeOOH) and hematite (α-Fe2O3) was assessed when exposed to aqueous sulfide (S(-II)aq) at pH 8.0. With both minerals, competition between S(-II) and U(VI) for surface sites caused instantaneous release of adsorbed U(VI). Compared to lepidocrocite, consumption of S(-II)aq proceeded slower with hematite, but yielded maximum dissolved U concentration...

A crucial limitation for structural and biophysical analysis of G protein-coupled receptors (GPCRs) is the inherent challenge of purifying and stabilizing these receptors in an active (agonist-bound) conformation. Peptide ligands, such as the vasoactive, cyclic hormone urotensin-II (U-II), may provide new purification tools, via high affinity, pseudo-irreversible binding suitable for ligand-bas...