objective(s) the process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. systemic administration of l-arginine promotes wound healing but its global side effects are undesirable. to confine the action of l-arginine at the site of injury, we tested the effects of local administration of l-arginine on the healing of excision...

A randomized, double-blind, placebo-controlled study in patients with clinical symptoms of stable angina pectoris and healed myocardial infarction (n = 22) has shown that oral supplementation with L-arginine (6 g/day for 3 days) increases exercise capacity (tested on a Marquette case 12 treadmill according to the modified Bruce protocol). Results suggest that the inefficient L-arginine/nitric o...

nucleus accumbens (nac) has been considered as a center for the induction of drug dependence. since a high concentration of the enzyme, nitric oxide synthase (nos) has been found in the nac, and this fact that the role of nitric oxide (no) in acquisition and expression of drug dependence has become clear in recent years, therefore in this study the effects of intraaccumbal injections of l-argin...

We investigated the combined effect of dietary supplementation with L-arginine, which is the precursor of NO, and pharmacological treatment with atorvastatin, which is a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor, on the development of atherosclerosis in homozygous Watanabe heritable hyperlipidaemic rabbits. Rabbits were fed either standard rabbit chow (group C; n 9) as control, a...

A manganese peroxidase gene (mnp1) from Phanerochaete chrysosporium was efficiently expressed in Aspergillus oryzae. Expression was achieved by fusing the mature cDNA of mnp1 with the A. oryzae Taka amylase promoter and secretion signal. The 3' untranslated region of the glucoamylase gene of Aspergillus awamori provided the terminator. The recombinant protein (rMnP) was secreted in an active fo...

introduction: nitric oxide (no), as a free radical, involves in several physiologic functions in gi tract such as nerve impulse transmission and vascular tonicity regulation. nitric oxide synthase (nos) is the enzyme for the production of no from l-arginine which in turn inhibits by l-ngnitroarginine methyl ester (l-name). in the current work, we aimed to evaluate morphometric analysis of duode...

introduction: the aim of the present study was to evaluate the effect of exercise training and l-arginine supplementation on oxidative stress and systolic ventricular function in rats with myocardial infarction (mi). methods: four weeks after the surgically-induced mi, 40 male wistar rats were randomly assigned to the following 4 groups (n=10): mi-sedentary control (sed) mi-exercise (ex) mi-sed...

L-arginine, an amino acid with a growing range of applications within the pharmaceutical, cosmetic, food, and agricultural industries, can be produced by microbial fermentation. Although it is the most nitrogen-rich amino acid, reports on the nitrogen supply for its fermentation are scarce. In this study, the nitrogen supply for the production of L-arginine by a genetically modified Escherichia...