Today’s businesses continually search for ways to increase productivity. To achieve this goal, shorter product development cycles and shorter manufacturing times are required. In both cases, problems that may arise during development must be identified much faster. In product development, this is done using virtual prototypes that can be easily duplicated and shared between everyone involved. I...

The aim of this paper is to improve the quality level by finding out the root causes of the quality related problems. Quality control tools are important tools used widely at manufacturing field to monitor the overall operation and continuous process improvement. Check Sheet, Pareto Diagram, Histogram, Cause-and-effect diagram, Control Chart, Run-Chart and Scatter-Diagram are used in enhancing ...

A local and temporal separated manufacturing becomes possible, which can enhance the economic efficiency of the production. Complex products such as spacecraft, large CNC Machine, large compressor face challenges in their development process. The cloud manufacturing which is based on the development of cloud computing and Internet of Things system makes the collaborative manufacturing process o...

selecting an appropriate manufacturing machine is a very important and complex problem for firms, which usually have to deal with both qualitative and quantitative criteria. taking into account the differences among machines in terms of cost, speed, quality and after sale services, type and number of machines are important parameters to consider. therefore, the goal of this paper is to propose ...

present research involves the complete simulation of pultrusion manufacturing process of glass/polyester composites. for that purpose, the curing process is divided to two liquid and gel-solid phases. the physical characteristics of the resin consist of specific heat, viscosity and coefficient of heat transfer changes with variations of temperature and increasing the degree of curing process (α...

In order to find out the key input parameters, which aroused the output quality out of control during the manufacturing process, an integrated quality diagnosis algorithm for input parameters was proposed. The diagnosis method extends the traditional quality control and diagnosis method that only for the output quality of manufacturing process. It can detect the input parameters of the manufact...

Background The adoption of Quality by Design (QbD) approach to biologics manufacturing requires fundamental understanding of complex relationship between the quality of the product, especially critical quality attributes (CQAs), and various parameters of the manufacturing process [1]. This can be approached through multivariate analysis of historical cell culture bioprocess data [2]. In this st...

Process capability indices are considered as an important concept in statistical quality control. They have been widely used in the manufacturing industry to provide numerical measures on process performance. Moreover, some incapability indices have been introduced to account the process performance. In this paper, we focus on the one proposed by Chen ~cite{Che:Stat}. In today's modern world, a...

Manufacturing produces real wealth for any country and constitutes the back bone for the service sector. The objective of any organization is to earn profit. Usually the market fixes the selling price of the manufactured components. Unless there is focus on the manufacturing strategy of reducing manufacturing cost, it is very difficult to sustain in this ever competitive world. A suitable manuf...

Process development and optimisation studies for the manufacturing process of N-methyl paroxetine was done by applying Quality by Design (QbD) principles. A normal operating range was defined for each process parameter by technique of design of experiments and knowledge of process chemistry to ensure consistent high quality of advanced intermediate and control of impurities. Initial challenges ...