Management strategies of patients with chronic-phase chronic myeloid leukemia (CML) have been revolutionized by the BCR-ABL-selective kinase inhibitor imatinib, which is substantially improving median survival. However, a proportion of patients suffer progressive disease on imatinib therapy. Importantly, patients who are particularly at risk for developing progressive disease can be identified ...

Thomas M. Lehmann, Henning Müller, Qi Tian, Nikolas P. Galatsanos, and Daniel Mlynek 1) Dept. of Medical Informatics, RWTH Aachen University of Technology, Aachen, Germany 2) Medical Informatics Service, University Hospitals of Geneva, Geneva, Switzerland 3) Inst. f. Infocomm Research, Agency for Science, Techn. and Research (A*Star), Singapore 4) Biom. Research Inst., Found. for Research & Tec...

Cancer is a genetic disease resulting from the mutations, either inherited or acquired, altering the normal genes to abnormal ‘oncogenes’. These in turn lead through a complicated cascade of biochemical signals to uncontrolled proliferation of the affected cells, which have the properties of autonomy (independent growth), metastasis (spread to other organs), dysplasia (altered structure of the ...

Tuberculosis (TB) is an infectious chronic disease. After decades of steadily declining prevalence, the disease has reemerged in the last 5 years. Symptoms of TB are mild and not specific and can be classified as either systemic or localized to target organs. Microscopic examination of the sputum remains an inexpensive and rapid way to identify highly infectious patients. Four different antimic...

DR. DOLILERY, Moderator: The symposium this afternoon is on the medical management of hypertension, and most of us would agree that this covers the great majority of cases of hypertension. We are to have three short papers and then a discussion. The first speaker is Dr. Mitchell Perry, of St. Louis, and he will speak on "Etiology and Natural History of Hypertension." DR. PERRY: Diastolic hypert...

Management of stroke has been revolutionised over the past decade, and therapeutic nihilism is no longer justified. The advent of acute treatments, especially thrombolysis, where the window of opportunity for intervention is very short and the treatment carries risk, emphasises the paramount importance of correct clinical diagnosis. Neurologists will need to adopt a front line role that is unfa...