Multiple sclerosis (MS) is a multifactorial disorder caused by the effects of several genes in combination with environmental factors. This disease is characterized by myelin loss, varying degrees of axonal pathology and inflammatory lesions. It is an important cause of disability in young adults, seen to be more prevalent in the woman, and affects 2.5 million people worldwide. Great efforts ar...

23 図 うつ病と脳卒中リスクの関連を検討した変量効果メタアナリシスのフォレストプロット。研究 0.25 0.5 1 2 4 8Vogt,1994 年Everson,1998 年Jonas,2000 年Larson,2001 年Ohira,2001 年Ostir,2001 年Wassertheil-Smoller,2004 年Gump,2005 年Kamphuis,2006 年Arbelaez,2007 年Salaycik,2007 年Bos,2008 年Liebetrau,2008 年Surtees,2008 年Wouts,2008 年Glymour,2010 年Nabi,2010 年全体0.84(0.57~ 1.2...

PY R I D O X A L 5 -P H O S P H A T E (PLP), the principal active coenzyme form of vitamin B6, is involved in almost 100 enzymatic reactions. One function of vitamin B6 is its role in the 1-carbon metabolic pathway, which involves the transfer of 1-carbon groups for DNA synthesis and DNA methylation. Deficiency of vitamin B6 has been associated with considerably impaired 1-carbon metabolism in ...

This two-volume publication contains the proceedings of a NATO Advanced Study Institute, held in April 1978. The material is organized in five sections. In the first section J. Bonner presents a historic review of chromatin research. The following section describes biophysical and chemical methods used in the study of isolated chromatin, such as electron microscopy, circular dichroism, X-ray di...

Abstract Introduction: Pregnancy is one of the most sensitive periods in a woman's life. Physical and psychological changes during pregnancy can significantly affect the couples' sexual relations. Healthy sexual desire during pregnancy is essential for the development of couples as parents. Objective: This meta-analysis study estimates the prevalence of sexual dysfunction overall and in diffe...