Recently, we identified the "apoptotic ring," containing phosphorylated histone H2AX (γ-H2AX), as an early chromatin modification during apoptosis. Because γ-H2AX initiates the DNA damage response (DDR), we tested whether the apoptotic H2AX response leads to the full recruitment of the DDR factors that normally coordinate DNA repair and cell-cycle checkpoints. We show that the apoptotic H2AX re...

Recently, we identified the "apoptotic ring," containing phosphorylated histone H2AX (g-H2AX), as an early chromatin modification during apoptosis. Because g-H2AX initiates the DNA damage response (DDR), we tested whether the apoptotic H2AX response leads to the full recruitment of the DDR factors that normally coordinate DNA repair and cell-cycle checkpoints. We show that the apoptotic H2AX re...

periodontal regeneration is a main aspect in the treatment of teeth affected by periodontitis. periodontal regeneration in furcation areas is quite challenging, especially when it is in interproximal region. there are several techniques used alone or in combination considered to achieve periodontal regeneration, including the bone grafts or substitutes, guided tissue regeneration (gtr), root su...

HYPERACUTE REJEcrION of human renal allografts in ABO compatible cases was first reported by TerasakU Kissmeyer-Nielson,~ Williams,3 and Starzl-l have further documented this problem, which has now been encountered in many active-transplant centers. Hyperacute rejection is initiated by preformed antidonor antibodies and may result in the destruction of the transplant within minutes of vasculari...

Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the releva...