Rats were trained for multiple sessions in a place-conditioning shuttle-box to explore motivational interactions of mu and kappa opioid agonists, specifically fentanyl reward and spiradoline aversion. In Phase 1, groups of rats received various doses of mu or kappa agonists, or placebo, testing for preference or aversion. Group A always received saline SC before 15-minute sessions. Group B rece...

introduction: previous studies have shown that sesame oil affects memory and learning. in the present work, effect of a diet containing 10% sesame oil used during pregnancy was evaluated on short-term passive avoidance learning of offspring rats by shuttle box. methods: female wistar rats were divided into 2 groups (n = 9 each group). control group consumed regular diet during pregnancy and the...

background lead poisoning impairs memory and learning. objectives the protective effect of natural zeolite clinoptilolite on memory and learning impairment in rats exposed to lead acetate was investigated. materials and methods 60 male wistar rats in six groups treated for 2 months with diets contained different ratios of natural zeolite(i.e. 5% or 12.5%), and %0.2 lead acetate (la) concentrati...

Introduction: Intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) to rodents has been reported as an appropriate model for sporadic dementia of Alzheimer's type (SDAT), characterized by a progressive impairment of memory. However, very little or nothing is known about non-cognitive behavioral effects in the STZ model. This study was carried out in order to show the protective eff...

Introduction: Previous studies have shown that sesame oil affects memory and learning. In the present work, effect of a diet containing 10% sesame oil used during pregnancy was evaluated on short-term passive avoidance learning of offspring rats by Shuttle box. Methods: Female Wistar rats were divided into 2 groups (n = 9 each group). Control group consumed regular diet during pregnancy and...

Physical activity reduces the incidence and severity of psychiatric disorders such as anxiety and depression. Similarly, voluntary wheel running produces anxiolytic- and antidepressant-like effects in rodent models. The specific neurobiological mechanisms underlying the beneficial properties of exercise, however, remain unclear. One relevant pharmacological target in the treatment of psychiatri...