Chemotherapeutic agent, busulfan, induce oxidative stress as a mechanism to kill cancer cells, however, it may also cause in non-target tissues and thereby lead normal tissue injury. Milk thistle (Silybum marianum L.) has been used for centuries herbal drug. The present study was carried out investigate the potential effects of wild Silybum seed ethanol extract (SMSEE) intervention on induced b...

The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle ( Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin ...

Flavonolignans are the main components of silymarin, which represents 1.5-3% of the dry fruit weight of Milk thistle (Silybum marianum L. Gaernt.). In ancient Greece and Romania, physicians and herbalists used the Silybum marianum to treat a range of liver diseases. Besides their hepatoprotective action, silymarin flavonolignans have many other healthy properties, such as anti-platelet and anti...

Abstract This investigation was aimed to evaluate the effects of Silybum marianum seed, Thymus vulgaris , and Rosmarinus officinalis powders their combination in alleviating risks aflatoxin B1 (AFB1) young broiler chicks. One-day-old Ross 308 male chickens were allocated 6 experimental groups from d 1 21. The dietary included: Negative control (NC) received basal diet, Positive (PC) containing ...

conclusions intake of water extract of silybum marianum is a useful treatment for liver function in drug-induced fatty liver. results concentrations of hdl-c and protein decreased and activity of alt increased in tmx group compared with the control group. the sme increased protein concentration and decreased alt activity in tmx-sme group compared with the tmx group. histopathological examinatio...