BACKGROUND Within the plastic surgery community, it is widely believed that waiting a minimum of 6 to 12 months after patient cessation of systemic retinoid therapy is necessary before proceeding with elective surgery. OBJECTIVE The authors investigate partial- and full-thickness wound healing after treatment with systemic isotretinoin in a porcine model. METHODS Following institutional app...

Introduction: Re-epithelialisation of cutaneous wounds is a complex multistep process. In partial thickness wounds, keratinocytes from wound edges and the remnants of the epidermal appendages contribute to the process. We investigated whether the mechanism of injury had any influence on reepithelialisation of partial thickness wounds in a porcine model. Method: Partial thickness wounds were cre...

Diabetic foot ulcerations are historically difficult to treat despite advanced therapeutic modalities. There are numerous modalities described in the literature ranging from noninvasive topical wound care to more invasive surgical procedures such as primary closure, skin flaps, and skin grafting. While skin grafting provides faster time to closure with a single treatment compared to traditional...

Silver sulfadiazine has been used as topical medication in the treatment of partial-thickness burns or secondary degree burns for many years. Pain during daily wound cleansing is the main problem. Urgotul SSD, a hydrocolloid dressing with silver sulfadiazine (SSD) has been reported to reduce infection and exhibit antimicrobial activity in burn wounds. The purpose of the present study was to com...

results the average percentage of wound healing in different groups on days 3, 6, 9 and 12 were as follows; 21.3%, 37.87%, 67.39% and 77.17% in control group; 24.98%, 34.21%, 70.74% and 88.55% in positive control group; and 32.35%, 61.27%, 94.53%, and 99.91%, in case group. a significant difference was observed between the control and case groups (p < 0.05). conclusions treatment with the studi...

Objective: To explore the methods for the repair of large-area limb skin avulsion wound. Method: Eleven patients with simple limb skin avulsion underwent large-area stereotypy full-thickness skin graft for wound repair. Results: Wounds were repaired very well as well as the late appearance and functions were satisfactory in all 11 patients. During follow-up, the hypertrophic scars were mild, th...

Emerging bacterial resistance to multiple drugs is an increasing problem in burn wound management. New non-pharmacologic interventions are needed for burn wound disinfection. Here we report on a novel physical method for disinfection: antiseptic pulsed electric field (PEF) applied externally to the infected burns. In a mice model, we show that PEF can reduce the load of multidrug resistant Acin...

UNLABELLED Reliable measures of wound size are critical to wound healing research and clinical management. Measurement of full-thickness wounds is increasingly being done using digital images and photogrammetric software, such as VeVMD (Vista Medical, Winnipeg, Manitoba, Canada), to estimate wound volume. The reliability of VeVMD in determining wound volume is unknown. The present study sought ...

The human placenta, a complex organ, which facilitates exchange between the fetus and the mother, contains abundant extracellular matrix (ECM) components and well-preserved endogenous growth factors. In this study, we designed a new dermal substitute from human placentas for full-thickness wound healing. Highly porous, decellularized ECM sheets were fabricated from human placentas via homogeniz...