OBJECTIVES To investigate the frequency and age at diagnosis of autism spectrum disorder (ASD) in children aged under 7 years living in Australia. DESIGN AND PARTICIPANTS Analysis of de-identified data on 15 074 children aged under 7 years registered with the Helping Children with Autism Package (HCWAP; a program that provides funding for access to early intervention and support services thro...

estimate mouse hen-egg white lysozyme (HEL)-anaphylaxis, including fatal shock. This assay system monitors the decrease in blood pressure or blood flow as anaphylaxis response and makes possible investigation of the dynamics of the anaphylactic response in the same individual animals without killing them. We have also discovered a distinctive phenomenon in which the blood flow of vein microcirc...

tions, such as atherosclerosis, cardiac dysfunction, retinopathy, neuropathy, and nephropathy. In longitudinal hyperglycemia, advanced glycation end-product (AGE) formation, resulting from the non-enzymatic reactions of carbohydrates and oxidized lipids with proteins, is increased and is also stimulated by oxidative stress which is closely linked with the pathogenesis of diabetic complications ...

advantages as an alternative dosage form (i) avoiding firstpass metabolism, (ii) easy discontinuation of administration, and (iii) reduced side effects; however, the stratum corneum, which is the outermost layer of skin, provides a primary barrier to transdermal drug delivery. Pentazocine (PTZ), a relatively short-acting narcotic-antagonist analgesic, is used clinically for the relief of cancer...

Cochlear implantation is currently the treatment of choice for children with severe to profound hearing impairment. However, the outcomes with cochlear implants (CIs) vary significantly among recipients. The purpose of the present study is to identify the genetic determinants of poor CI outcomes. Twelve children with poor CI outcomes (the "cases") and 30 "matched controls" with good CI outcomes...

AIM To study the effect of a warm up schedule on exercise-induced asthma in asthmatic children to enable them to engage in asthmogenic activities. METHOD In the first study, peak flows during and after three short, repeated warm up schedules (SRWU 1, 2, and 3), identical in form but differing in intensity, were compared in 16 asthmatic children. In the second study the efficiency of the best ...

The present research investigates how a global pandemic may be affecting children’s understanding of contagion. In Study 1, 130 parents (85.4 % White, 6.9 Hispanic, 3.8 Asian, Black) children ages 3–9 described discussions surrounding contagion pre- and post-pandemic. Content these focused on risks preventative behaviors rather than causal mechanisms 2, US tested during the (ages 4?7, N = 60, 5...