2056 Background: 5-Fluorouracil (5-FU) is an integral part of treatment of GI malignancies. While normal DPD enzyme activity is rate limiting in 5-FU catabolism, its deficiency could increase concentrations of bioavailable 5-FU anabolic products leading to 5-FU related toxicity syndrome. With DPD deficiency, 5-FU is discontinued. Data regarding safety of capecitabine (CAP) in this population is...


 This review identified limited evidence regarding the clinical effectiveness of raltitrexed for patients who had previously experienced adverse events following treatment with fluoropyrimidines. These studies several limitations, most notably lacking a separate control group; therefore, in this population is uncertain.
 Limited was found about safety fluoropyrimidine treatment. Repo...

A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...

A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...

the antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. significant antimicrobial activity (mic=32, 64 µg/ml) was observed. escherichia coli and pseudomonas aeruginosa as gram-negative bacteria and staphylococcus aureus as gram-positive bacteria were determined to be the most susceptible pathogens in this study. the highest ...