Asthma is a disease characterized by spontaneous contraction of the airways in response to a wide variety of endogenous and exogenous stimuli. Many asthma models are used to mimic the human asthma model in the literature. In order to better understand the role of the cannabinoid (CB) 2 receptor in the ovalbumin (OVA)-induced asthma model, a combination of both selective CB2 agonist (AM1241) and...

The aim of this study was to investigate the effects of magnesium as a N-Methyl–D-Aspartate (NMDA) receptor Antagnist and bromocriptine as a dopamine receptor agonist on morphine dependence and withdrawal symptoms. In the present study different groups of mice were received morphine (50 mg/kg, i.p.) for four days and on fourth day 1.5 hour after the last morphine administration they received di...

Background: This study aims to verify if luteal estradiol pre-treatment improves IVF/ICSI outcomes in a GnRH antagonist protocol as compared to a micro dose GnRH agonist protocol in poor-responding patients. Materials and Methods: A total of 116 IVF/ICSI cycles were included in this prospective randomized clinical trial. The selected women were randomly assigned to receive an estradiol pre-trea...

Nearly 30 years have passed since the first selective 5-HT1 receptor agonist sumatriptan became a choice of treatment for migraineurs. Recently, new class antimigraine drugs has joined antimig...

Background: Application of haptens to the skin induces release immune stimulatory adenosine triphosphate into extracellular space. This “danger” signal can be converted immunosuppressive by action ectonucleotidases CD39 and CD73, expressed cells. CD73 deficient mice have thicker ear swelling 1 day after challenge. On other hand, neutrophil is also essential induce contact hypersensitivity(CHS) ...