BACKGROUND Circulating antipituitary antibodies (APA) are markers of autoimmune hypophysitis, which may cause deficient pituitary function. The prevalence of APA in autoimmune thyroid disorders (AITD) is uncertain. OBJECTIVES The aims of this study were 1) to evaluate APA prevalence in a large series of patients with AITD and non-AITD and 2) to investigate the functional significance of APA b...

Alternative polyadenylation (APA), which induces shortening of the 3'UTR, is emerging as an important phenomenon in gene regulation. APA is involved in development, cancer and cell proliferation. APA may lead to disruption of microRNA-mediated gene silencing in cancer cells via detachment of microRNA binding sites. We studied the correlation between the APA profile and the tumor aggressiveness ...

Alternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability, translation, and translocation in cells. However, genome-wide APA events have only recently been subjected to more systematic analysis with newly developed high-throughput methods. In this review, we focus on the recent technological development of APA analyses on a genome-wide scale, as we...

Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF -2549 insertion/deletion (I/...

background: the study of the association between genotype and phenotype is of great importance for the prediction of many diseases and pathophysiological conditions. the relationship between angiotensin-converting enzyme (ace) gene insertion/ deletion (i/d) polymorphism and pathological processes such as coronary artery disease (cad) has been investigated previously with discordant results. thi...

The potential aminopeptidase activity (APA) vis-a-vis important ecological parameters of surface and bottom waters of Uranouchi Inlet (Japan), a semi-enclosed eutrophic coastal ecosystem, were studied on a weekly to biweekly basis from mid-August 1996 to early November 1997. The aim of this study was to investigate the main factors regulating the annual and seasonal dynamics of APA in the inlet...

We propose a gradient-limited affine projection algorithm (GL-APA), which can achieve fast and double-talk-robust convergence in acoustic echo cancellation. GL-APA is derived from the M-estimationbased nonlinear cost function extended for evaluating multiple error signals dealt with in the affine projection algorithm (APA). By considering the nonlinearity of the gradient, we carefully formulate...

The vitamin D endocrine system regulates bone metabolism and calcium homeostasis as well as cellular proliferation and differentiation. Vitamin D receptor (VDR) mediates Vit-D activity, thus VDR gene polymorphisms may correlate with different diseases. This study aimed to determine the distribution of VDR gene (Taq-I and Apa-I) polymorphisms using a RFLP in unrelated normal healthy individuals ...

to study the newly mentioned significance of the obstructive lesion morphology in coronary artery disease (cad), a study has been designed to compare this feature between patients having stable angina (sa) or unstable angina (ua) who underwent coronary angiography in tehran heart institute. study objectives were detection of the angina producing artery (ap a) and its morphologic lesion type, de...